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A sequential targeting strategy interrupts AKT-driven subclone-mediated progression in glioblastoma

Therapy resistance and fatal disease progression in glioblastoma are thought to result from the dynamics of intra-tumor heterogeneity. This study aimed at identifying and molecularly targeting tumor cells that can survive, adapt, and subclonally expand under primary therapy.To identify candidate mar...

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Bibliographic Details
Main Authors: Kebir, Sied (Author) , Herold-Mende, Christel (Author) , Scheffler, Björn (Author)
Format: Article (Journal)
Language:English
Published: 15 January 2023
In: Clinical cancer research
Year: 2023, Volume: 29, Issue: 2, Pages: 488-500
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-22-0611
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/1078-0432.CCR-22-0611
Verlag, lizenzpflichtig, Volltext: https://aacrjournals.org/clincancerres/article/29/2/488/713980/A-Sequential-Targeting-Strategy-Interrupts-AKT
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Author Notes:Sied Kebir, Vivien Ullrich, Pia Berger, Celia Dobersalske, Sarah Langer, Laurèl Rauschenbach, Daniel Trageser, Andreas Till, Franziska K. Lorbeer, Anja Wieland, Timo Wilhelm-Buchstab, Ashar Ahmad, Holger Fröhlich, Igor Cima, Shruthi Prasad, Johann Matschke, Verena Jendrossek, Marc Remke, Barbara M. Grüner, Alexander Roesch, Jens T. Siveke, Christel Herold-Mende, Tobias Blau, Kathy Keyvani, Frank K.H. van Landeghem, Torsten Pietsch, Jörg Felsberg, Guido Reifenberger, Michael Weller, Ulrich Sure, Oliver Brüstle, Matthias Simon, Martin Glas, and Björn Scheffler
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Summary:Therapy resistance and fatal disease progression in glioblastoma are thought to result from the dynamics of intra-tumor heterogeneity. This study aimed at identifying and molecularly targeting tumor cells that can survive, adapt, and subclonally expand under primary therapy.To identify candidate markers and to experimentally access dynamics of subclonal progression in glioblastoma, we established a discovery cohort of paired vital cell samples obtained before and after primary therapy.
Item Description:Online veröffentlicht am 14. Oktober 2022
Gesehen am 28.11.2023
Physical Description:Online Resource
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-22-0611

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