Common mechanisms in pediatric acute liver failure
Acute liver failure (ALF) is a rare but potentially fatal disease in children. The etiology is multifactorial, including infection, autoimmune, and genetic disorders, as well as indeterminate hepatitis, which has a higher requirement for liver transplantation. Activation of the innate and adaptive i...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 February 2023
|
| In: |
Trends in molecular medicine
Year: 2023, Jahrgang: 29, Heft: 3, Pages: 228-240 |
| ISSN: | 1471-499X |
| DOI: | 10.1016/j.molmed.2022.11.006 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.molmed.2022.11.006 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1471491422002994 
|
| Verfasserangaben: | Jake P. Mann, Dominic Lenz, Zania Stamataki, and Deirdre Kelly |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1840306203 | ||
| 003 | DE-627 | ||
| 005 | 20230706214714.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230328s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.molmed.2022.11.006 |2 doi | |
| 035 | |a (DE-627)1840306203 | ||
| 035 | |a (DE-599)KXP1840306203 | ||
| 035 | |a (OCoLC)1389531150 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Mann, Jake P. |e VerfasserIn |0 (DE-588)1076336124 |0 (DE-627)834717794 |0 (DE-576)445212438 |4 aut | |
| 245 | 1 | 0 | |a Common mechanisms in pediatric acute liver failure |c Jake P. Mann, Dominic Lenz, Zania Stamataki, and Deirdre Kelly |
| 264 | 1 | |c 15 February 2023 | |
| 300 | |a 16 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar 7 Dezember 2022, Artikelversion 15 Februar 2023 | ||
| 500 | |a Gesehen am 28.03.2023 | ||
| 520 | |a Acute liver failure (ALF) is a rare but potentially fatal disease in children. The etiology is multifactorial, including infection, autoimmune, and genetic disorders, as well as indeterminate hepatitis, which has a higher requirement for liver transplantation. Activation of the innate and adaptive immune systems leads to hepatocyte-specific injury which is mitigated by T regulatory cell activation. Recovery of the native liver depends on activation of apoptotic and regenerative pathways, including the integrated stress response (ISR; e.g., PERK), p53, and HNF4α. Loss-of-function mutations in these pathways cause recurrent ALF in response to non-hepatotropic viruses. Deeper understanding of these mechanisms will lead to improved diagnosis, management, and outcomes for pediatric ALF. | ||
| 650 | 4 | |a acute liver failure | |
| 650 | 4 | |a adenovirus | |
| 650 | 4 | |a hepatocyte regeneration | |
| 650 | 4 | |a integrated stress response | |
| 700 | 1 | |a Lenz, Dominic |d 1984- |e VerfasserIn |0 (DE-588)1047559943 |0 (DE-627)778553914 |0 (DE-576)401159140 |4 aut | |
| 700 | 1 | |a Stamataki, Zania |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kelly, Deirdre |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Trends in molecular medicine |d Amsterdam [u.a.] : Elsevier Science, 2001 |g 29(2023), 3, Seite 228-240 |h Online-Ressource |w (DE-627)391368036 |w (DE-600)2155736-6 |w (DE-576)252209338 |x 1471-499X |7 nnas |a Common mechanisms in pediatric acute liver failure |
| 773 | 1 | 8 | |g volume:29 |g year:2023 |g number:3 |g pages:228-240 |g extent:16 |a Common mechanisms in pediatric acute liver failure |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.molmed.2022.11.006 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S1471491422002994 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230328 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1047559943 |a Lenz, Dominic |m 1047559943:Lenz, Dominic |d 910000 |d 910500 |e 910000PL1047559943 |e 910500PL1047559943 |k 0/910000/ |k 1/910000/910500/ |p 2 | ||
| 999 | |a KXP-PPN1840306203 |e 429859954X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Online verfügbar 7 Dezember 2022, Artikelversion 15 Februar 2023","Gesehen am 28.03.2023"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1840306203","language":["eng"],"person":[{"display":"Mann, Jake P.","roleDisplay":"VerfasserIn","role":"aut","family":"Mann","given":"Jake P."},{"family":"Lenz","given":"Dominic","display":"Lenz, Dominic","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Stamataki","given":"Zania","roleDisplay":"VerfasserIn","display":"Stamataki, Zania","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Kelly, Deirdre","given":"Deirdre","family":"Kelly"}],"title":[{"title_sort":"Common mechanisms in pediatric acute liver failure","title":"Common mechanisms in pediatric acute liver failure"}],"physDesc":[{"extent":"16 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedDisp":"2001-","dateIssuedKey":"2001","publisher":"Elsevier Science"}],"id":{"issn":["1471-499X"],"eki":["391368036"],"zdb":["2155736-6"]},"disp":"Common mechanisms in pediatric acute liver failureTrends in molecular medicine","note":["Gesehen am 21.11.23"],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"recId":"391368036","pubHistory":["7.2001 -"],"part":{"year":"2023","issue":"3","pages":"228-240","volume":"29","text":"29(2023), 3, Seite 228-240","extent":"16"},"title":[{"title":"Trends in molecular medicine","title_sort":"Trends in molecular medicine"}]}],"name":{"displayForm":["Jake P. Mann, Dominic Lenz, Zania Stamataki, and Deirdre Kelly"]},"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"15 February 2023"}],"id":{"doi":["10.1016/j.molmed.2022.11.006"],"eki":["1840306203"]}} | ||
| SRT | |a MANNJAKEPLCOMMONMECH1520 | ||