Notch signaling in the vasculature: angiogenesis and angiocrine functions

Formation of a functional blood vessel network is a complex process tightly controlled by pro- and antiangiogenic signals released within the local microenvironment or delivered through the bloodstream. Endothelial cells precisely integrate such temporal and spatial changes in extracellular signals...

Full description

Saved in:
Bibliographic Details
Main Author: Safatul Hasan, Sana (Author)
Other Authors: Fischer, Andreas (Other)
Format: Article (Journal)
Language:English
Published: March 2023
In: Cold Spring Harbor perspectives in medicine
Year: 2023, Volume: 13, Issue: 2, Pages: 1-18
ISSN:2157-1422
DOI:10.1101/cshperspect.a041166
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1101/cshperspect.a041166
Verlag, lizenzpflichtig, Volltext: https://perspectivesinmedicine.cshlp.org/content/13/2/a041166
Get full text
Author Notes:Sana S. Hasan and Andreas Fischer

MARC

LEADER 00000caa a2200000 c 4500
001 1840343435
003 DE-627
005 20230706214632.0
007 cr uuu---uuuuu
008 230328s2023 xx |||||o 00| ||eng c
024 7 |a 10.1101/cshperspect.a041166  |2 doi 
035 |a (DE-627)1840343435 
035 |a (DE-599)KXP1840343435 
035 |a (OCoLC)1389531136 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Safatul Hasan, Sana  |d 1989-  |e VerfasserIn  |0 (DE-588)1126282618  |0 (DE-627)880884800  |0 (DE-576)484467166  |4 aut 
245 1 0 |a Notch signaling in the vasculature  |b angiogenesis and angiocrine functions  |c Sana S. Hasan and Andreas Fischer 
264 1 |c March 2023 
300 |a 18 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 28.03.2023 
520 |a Formation of a functional blood vessel network is a complex process tightly controlled by pro- and antiangiogenic signals released within the local microenvironment or delivered through the bloodstream. Endothelial cells precisely integrate such temporal and spatial changes in extracellular signals and generate an orchestrated response by modulating signaling transduction, gene expression, and metabolism. A key regulator in vessel formation is Notch signaling, which controls endothelial cell specification, proliferation, migration, adhesion, and arteriovenous differentiation. This review summarizes the molecular biology of endothelial Notch signaling and how it controls angiogenesis and maintenance of the established, quiescent vasculature. In addition, recent progress in the understanding of Notch signaling in endothelial cells for controlling organ homeostasis by transcriptional regulation of angiocrine factors and its relevance to disease will be discussed. 
650 4 |a brain arteriovenous-malformations 
650 4 |a endothelial notch 
650 4 |a hematopoietic stem 
650 4 |a inhibits tumor-growth 
650 4 |a ligand endocytosis 
650 4 |a mesenchymal transition 
650 4 |a self-renewal 
650 4 |a sprouting angiogenesis 
650 4 |a tip cell-formation 
650 4 |a vessel formation 
700 1 |a Fischer, Andreas  |d 1976-  |0 (DE-588)124869955  |0 (DE-627)367234300  |0 (DE-576)294543511  |4 oth 
773 0 8 |i Enthalten in  |t Cold Spring Harbor perspectives in medicine  |d Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press, 2011  |g 13(2023), 2, Artikel-ID a041166, Seite 1-18  |h Online-Ressource  |w (DE-627)668712260  |w (DE-600)2628603-8  |w (DE-576)350865256  |x 2157-1422  |7 nnas  |a Notch signaling in the vasculature angiogenesis and angiocrine functions 
773 1 8 |g volume:13  |g year:2023  |g number:2  |g elocationid:a041166  |g pages:1-18  |g extent:18  |a Notch signaling in the vasculature angiogenesis and angiocrine functions 
856 4 0 |u https://doi.org/10.1101/cshperspect.a041166  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://perspectivesinmedicine.cshlp.org/content/13/2/a041166  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20230330 
993 |a Article 
994 |a 2023 
998 |g 124869955  |a Fischer, Andreas  |m 124869955:Fischer, Andreas  |d 60000  |d 65000  |e 60000PF124869955  |e 65000PF124869955  |k 0/60000/  |k 1/60000/65000/  |p 2  |y j 
999 |a KXP-PPN1840343435  |e 4299813367 
BIB |a Y 
SER |a journal 
JSO |a {"id":{"eki":["1840343435"],"doi":["10.1101/cshperspect.a041166"]},"relHost":[{"id":{"issn":["2157-1422"],"zdb":["2628603-8"],"eki":["668712260"]},"disp":"Notch signaling in the vasculature angiogenesis and angiocrine functionsCold Spring Harbor perspectives in medicine","name":{"displayForm":["Cold Spring Harbor Laboratory"]},"physDesc":[{"extent":"Online-Ressource"}],"part":{"volume":"13","text":"13(2023), 2, Artikel-ID a041166, Seite 1-18","year":"2023","pages":"1-18","issue":"2","extent":"18"},"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 28.02.25"],"origin":[{"dateIssuedDisp":"2011-","dateIssuedKey":"2011","publisher":"Cold Spring Harbor Laboratory Press","publisherPlace":"Cold Spring Harbor, NY"}],"pubHistory":["1.2011 -"],"title":[{"title":"Cold Spring Harbor perspectives in medicine","title_sort":"Cold Spring Harbor perspectives in medicine"}],"recId":"668712260","titleAlt":[{"title":"Perspectives in medicine"},{"title":"CSH perspectives in medicine"}],"language":["eng"]}],"person":[{"display":"Safatul Hasan, Sana","family":"Safatul Hasan","given":"Sana","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Andreas","family":"Fischer","role":"oth","display":"Fischer, Andreas"}],"name":{"displayForm":["Sana S. Hasan and Andreas Fischer"]},"physDesc":[{"extent":"18 S."}],"origin":[{"dateIssuedDisp":"March 2023","dateIssuedKey":"2023"}],"note":["Gesehen am 28.03.2023"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title_sort":"Notch signaling in the vasculature","title":"Notch signaling in the vasculature","subtitle":"angiogenesis and angiocrine functions"}],"recId":"1840343435","language":["eng"]} 
SRT |a SAFATULHASNOTCHSIGNA2023