Systems analysis of iron metabolism: the network of iron pools and fluxes
Every cell of the mammalian organism needs iron as trace element in numerous oxido-reductive processes as well as for transport and storage of oxygen. The very versatility of ionic iron makes it a toxic entity which can catalyze the production of radicals that damage vital membranous and macromolecu...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 August 2010
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| In: |
BMC systems biology
Year: 2010, Jahrgang: 4, Pages: 1-18 |
| ISSN: | 1752-0509 |
| DOI: | 10.1186/1752-0509-4-112 |
| Online-Zugang: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/1752-0509-4-112 Verlag, lizenzpflichtig, Volltext: https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-4-112 
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| Verfasserangaben: | Tiago JS Lopes, Tatyana Luganskaja, Maja Vujić Spasić, Matthias W. Hentze, Martina U. Muckenthaler, Klaus Schümann, Jens G. Reich |
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| 520 | |a Every cell of the mammalian organism needs iron as trace element in numerous oxido-reductive processes as well as for transport and storage of oxygen. The very versatility of ionic iron makes it a toxic entity which can catalyze the production of radicals that damage vital membranous and macromolecular assemblies in the cell. The mammalian organism maintains therefore a complex regulatory network of iron uptake, excretion and intra-body distribution. Intracellular regulation in different cell types is intertwined with a global hormonal signalling structure. Iron deficiency as well as excess of iron are frequent and serious human disorders. They can affect every cell, but also the organism as a whole. | ||
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