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CNP promotes antiarrhythmic effects via phosphodiesterase 2

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Background: - - Ventricular arrhythmia and sudden cardiac death are the most common lethal complications after myocardial infarction. Antiarrhythmic pharmacotherapy remains a clinical challenge and novel concepts are highly desired. Here, we focus on the cardioprotective CNP (C-type natriuretic pep...

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Main Authors: Cachorro, Eleder (Author) , Günscht, Mario (Author) , Schubert, Mario (Author) , Sadek, Mirna S. (Author) , Siegert, Johanna (Author) , Dutt, Fabian (Author) , Bauermeister, Carla (Author) , Quickert, Susann (Author) , Berning, Henrik (Author) , Nowakowski, Felix (Author) , Lämmle, Simon (Author) , Firneburg, Rebecca (Author) , Luo, Xiaojing (Author) , Künzel, Stephan R. (Author) , Klapproth, Erik (Author) , Mirtschink, Peter (Author) , Mayr, Manuel (Author) , Dewenter, Matthias (Author) , Vettel, Christiane (Author) , Heijman, Jordi (Author) , Lorenz, Kristina (Author) , Guan, Kaomei (Author) , El-Armouche, Ali (Author) , Wagner, Michael (Author) , Kämmerer, Susanne (Author)
Format: Article (Journal)
Language:English
Published: 30 Jan 2023
In: Circulation research
Year: 2023, Volume: 132, Issue: 4, Pages: 400-414
ISSN:1524-4571
DOI:10.1161/CIRCRESAHA.122.322031
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1161/CIRCRESAHA.122.322031
Verlag, lizenzpflichtig, Volltext: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.322031
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Author Notes:Eleder Cachorro, Mario Günscht, Mario Schubert, Mirna S. Sadek, Johanna Siegert, Fabian Dutt, Carla Bauermeister, Susann Quickert, Henrik Berning, Felix Nowakowski, Simon Lämmle, Rebecca Firneburg, Xiaojing Luo, Stephan R. Künzel, Erik Klapproth, Peter Mirtschink, Manuel Mayr, Matthias Dewenter, Christiane Vettel, Jordi Heijman, Kristina Lorenz, Kaomei Guan, Ali El-Armouche, Michael Wagner, Susanne Kämmerer
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Pak2 regulation of Nrf2 serves as a novel signaling nexus linking ER stress response and oxidative stress in the heart by Binder, Pablo (Author) , Nguyen, Binh (Author) , Collins, Lucy (Author) , Zi, Min (Author) , Liu, Wei (Author) , Christou, Foteini (Author) , Luo, Xiaojing (Author) , Hille, Susanne S. (Author) , Frey, Norbert (Author) , Cartwright, Elizabeth J. (Author) , Chernoff, Jonathan (Author) , Müller, Oliver J. (Author) , Guan, Kaomei (Author) , Wang, Xin (Author) ,


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