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Treatment of recurrent bronchial carcinoma: the role of high-dose-rate endoluminal brachytherapy

Purpose - This study's aim was to assess outcome and toxicity of high-dose-rate endoluminal brachytherapy (HDREB) for recurrent bronchial carcinoma. - Methods and Materials - From 1987 to 2005, 41 patients were treated with HDREB for symptomatic recurrent bronchial carcinoma. All patients had p...

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Main Authors: Hauswald, Henrik (Author) , Stoiber, Eva Maria (Author) , Rochet, Nathalie (Author) , Lindel, Katja (Author) , Grehn, Christian J. (Author) , Becker, Heinrich D. (Author) , Debus, Jürgen (Author) , Harms, Wolfgang (Author)
Format: Article (Journal)
Language:English
Published: [1 June 2010]
In: International journal of radiation oncology, biology, physics
Year: 2010, Volume: 77, Issue: 2, Pages: 373-377
ISSN:1879-355X
DOI:10.1016/j.ijrobp.2009.05.041
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijrobp.2009.05.041
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0360301609008189
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Author Notes:Henrik Hauswald, Eva Stoiber, Nathalie Rochet, Katja Lindel, Christian Grehn, Heinrich D. Becker, Juergen Debus, and Wolfgang Harms

MARC

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245 1 0 |a Treatment of recurrent bronchial carcinoma  |b the role of high-dose-rate endoluminal brachytherapy  |c Henrik Hauswald, Eva Stoiber, Nathalie Rochet, Katja Lindel, Christian Grehn, Heinrich D. Becker, Juergen Debus, and Wolfgang Harms 
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520 |a Purpose - This study's aim was to assess outcome and toxicity of high-dose-rate endoluminal brachytherapy (HDREB) for recurrent bronchial carcinoma. - Methods and Materials - From 1987 to 2005, 41 patients were treated with HDREB for symptomatic recurrent bronchial carcinoma. All patients had previously undergone external beam radiotherapy (EBRT) with a median dose of 56 Gy (range, 30-70 Gy). The median HDREB dose applied was 15 Gy (range, 5-29 Gy). The median time interval between primary EBRT and reirradiation was 9 months (range, 2-54 months). - Results - After a median follow-up of 6.7 months, the 6-, 12-, and 24-month overall survival rates were 58%, 18%, and 7%, respectively. The median overall survival time was 6.7 months. Local remission was achieved in 73% of patients (n = 30). A total of 24% of patients (n = 10) showed no response or progressive disease within 8 weeks after treatment. In 1 patient, treatment response was not documented. The 6-, 12-, and 24-month local control rates were 38%, 17%, and 3%, respectively. The median local progression-free survival time was 4 months (range, 1-23 months). Prognostic factors were a total dose of ≥15 Gy of HDREB (p = 0.029) and a Karnofsky performance score of ≥80% (p = 0.0012). The cause of death was locoregional progression in 27% of patients (n = 11), distant metastases in 24% of patients (n = 10), fatal hemorrhage in 15% of patients (n = 6), and other causes in 29% of patients (n = 12). None of the patients with locally controlled disease showed grade 3 or 4 late effects. - Conclusions - Palliative treatment of symptomatic, locally recurrent bronchial carcinoma with HDREB can effectively relieve symptoms in the majority of patients while causing only few complications. Still, time to progression is short. 
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