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Loss of olfactory function after exposure to barbituric acid

In this case report a patient with anosmia due to occupational exposure to barbituric acid will be presented. Occupational exposure to high concentrations of barbituric acid resulted in bloody nasal secretion and nasal itching with immediate onset following exposure. After several days of exposure,...

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Hauptverfasser: Heiser, Clemens (VerfasserIn) , Grupp, Kathrin Frauke (VerfasserIn) , Hörmann, Karl (VerfasserIn) , Stuck, Boris (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: [February 2010]
In: Auris, nasus, larynx
Year: 2010, Jahrgang: 37, Heft: 1, Pages: 103-105
ISSN:1879-1476
DOI:10.1016/j.anl.2009.03.011
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.anl.2009.03.011
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S038581460900090X
Volltext
Verfasserangaben:C. Heiser, K. Grupp, K. Hörmann, B.A. Stuck (Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim)

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520 |a In this case report a patient with anosmia due to occupational exposure to barbituric acid will be presented. Occupational exposure to high concentrations of barbituric acid resulted in bloody nasal secretion and nasal itching with immediate onset following exposure. After several days of exposure, a progressive loss of smell resulted in anosmia. Psychophysical and electrophysiological assessment of olfactory function with the “Sniffiń Sticks” test and event-related potentials based on air dilution olfactometry confirmed the patients’ reports. After 2 years no recovery is remarked. Toxic anosmia has repeatedly been described due to exposure to chemicals, although barbituric acid has not been reported to be the cause of anosmia to date. Awareness of clinicians to toxic anosmia and the report of those cases appear to be mandatory to reduce occupational risks. 
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