Impact of chewing bags, e-cigarettes, and combustible cigarettes on arterial stiffness and small airway function in healthy students

Several substitute products are discussed as a healthier alternative to smoking, thereunder e-cigarettes and smokeless tobacco products, e.g., chewing bags, which are increasingly used in this context. We investigated the acute effects of chewing bags compared to combustible cigarettes and e-cigaret...

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Hauptverfasser: Hauck, Annabelle Susann (VerfasserIn) , Buchwald, Isabel (VerfasserIn) , Watz, Henrik (VerfasserIn) , Trinkmann, Frederik (VerfasserIn) , Söling, Charlotte (VerfasserIn) , Rabenstein, Andrea (VerfasserIn) , Ruether, Tobias (VerfasserIn) , Mortensen, Kai (VerfasserIn) , Drömann, Daniel (VerfasserIn) , Franzen, Klaas Frederik (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 14 January 2023
In: Toxics
Year: 2023, Jahrgang: 11, Heft: 1, Pages: 1-12
ISSN:2305-6304
DOI:10.3390/toxics11010077
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/toxics11010077
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2305-6304/11/1/77
Volltext
Verfasserangaben:Annabelle Susann Hauck, Isabel Buchwald, Henrik Watz, Frederik Trinkmann, Charlotte Söling, Andrea Rabenstein, Tobias Ruether, Kai Mortensen, Daniel Drömann and Klaas Frederik Franzen

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520 |a Several substitute products are discussed as a healthier alternative to smoking, thereunder e-cigarettes and smokeless tobacco products, e.g., chewing bags, which are increasingly used in this context. We investigated the acute effects of chewing bags compared to combustible cigarettes and e-cigarettes with and without nicotine on small airways and arterial stiffness in a head-to-head design. This single-center, four-arm cross-overstudy included 20 healthy occasional smokers (25 ± 0.6 years). On four test days, participants consumed one product per day. Before, during, and after consumption, peripheral and central hemodynamic as well as arterial stiffness parameters were measured by Mobil-O-Graph™ (I.E.M., Germany). Resistance and small airway function were assessed by tremoFlo® c-100 (THORASYS Thoracic Medical Systems Inc.). The combustible cigarette and the e-cigarettes with and without nicotine significantly increased the resistance of the small airways (p < 0.05), while chewing bags had no effect. All nicotine containing products (e-cigarette with nicotine, combustible cigarette, chewing bag) as well as the e-cigarette without nicotine significantly increased parameters of hemodynamic and arterial stiffness. Changes in blood pressure and arterial stiffness were similar after smoking, vaping, and using chewing bags. We conclude that e-cigarettes and combustible cigarettes have similar acute harmful effects on small airway dysfunction. All nicotine containing products are associated with an increased cardiovascular risk compared with no product use. 
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