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Modulatory activity of the Copper chelate, Copper N-(2-Hydroxy acetophenone) glycinate, in ABC-transporter-expressing cell lines

Metal-containing compounds (e.g., platinum complexes) belong to the standard armamentarium of cancer chemotherapy. Copper N-(2-hydroxy acetophenone) glycinate (CuNG) exerts anticancer activity in vitro and in vivo and modulates drug resistance related to glutathione or P-glycoprotein. The potential...

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Bibliographic Details
Main Authors: Hartinger, Eva-Maria (Author) , Mahringer, Anne (Author) , Choudhuri, Soumitra Kumar (Author) , Fricker, Gert (Author) , Efferth, Thomas (Author)
Format: Article (Journal)
Language:English
Published: March 2023
In: Anticancer research
Year: 2023, Volume: 43, Issue: 3, Pages: 1031-1041
ISSN:1791-7530
DOI:10.21873/anticanres.16248
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.21873/anticanres.16248
Verlag, lizenzpflichtig, Volltext: https://ar.iiarjournals.org/content/43/3/1031
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Author Notes:Eva-Maria Hartinger, Anne Mahringer, Soumitra Kumar Choudhuri, Gert Fricker and Thomas Efferth
Description
Summary:Metal-containing compounds (e.g., platinum complexes) belong to the standard armamentarium of cancer chemotherapy. Copper N-(2-hydroxy acetophenone) glycinate (CuNG) exerts anticancer activity in vitro and in vivo and modulates drug resistance related to glutathione or P-glycoprotein. The potential of CuNG to interact with ATP-binding cassette (ABC) transporters has not been fully explored yet. This study focused on the modulatory effects of CuNG on four ABC transporters (MRP1, MRP1, BCRP, and P-glycoprotein).
Item Description:Online veröffentlicht am 28. Februar 2023
Gesehen am 07.12.2023
Physical Description:Online Resource
ISSN:1791-7530
DOI:10.21873/anticanres.16248

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