Modulatory activity of the Copper chelate, Copper N-(2-Hydroxy acetophenone) glycinate, in ABC-transporter-expressing cell lines
Metal-containing compounds (e.g., platinum complexes) belong to the standard armamentarium of cancer chemotherapy. Copper N-(2-hydroxy acetophenone) glycinate (CuNG) exerts anticancer activity in vitro and in vivo and modulates drug resistance related to glutathione or P-glycoprotein. The potential...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 2023
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| In: |
Anticancer research
Year: 2023, Jahrgang: 43, Heft: 3, Pages: 1031-1041 |
| ISSN: | 1791-7530 |
| DOI: | 10.21873/anticanres.16248 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.21873/anticanres.16248 Verlag, lizenzpflichtig, Volltext: https://ar.iiarjournals.org/content/43/3/1031 
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| Verfasserangaben: | Eva-Maria Hartinger, Anne Mahringer, Soumitra Kumar Choudhuri, Gert Fricker and Thomas Efferth |
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| 520 | |a Metal-containing compounds (e.g., platinum complexes) belong to the standard armamentarium of cancer chemotherapy. Copper N-(2-hydroxy acetophenone) glycinate (CuNG) exerts anticancer activity in vitro and in vivo and modulates drug resistance related to glutathione or P-glycoprotein. The potential of CuNG to interact with ATP-binding cassette (ABC) transporters has not been fully explored yet. This study focused on the modulatory effects of CuNG on four ABC transporters (MRP1, MRP1, BCRP, and P-glycoprotein). | ||
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