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Identification of FOXP1 deletions in three unrelated patients with mental retardation and significant speech and language deficits

Mental retardation affects 2-3% of the population and shows a high heritability. Neurodevelopmental disorders that include pronounced impairment in language and speech skills occur less frequently. For most cases, the molecular basis of mental retardation with or without speech and language disorder...

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Main Authors: Horn, Denise (Author) , Kapeller, Johannes (Author) , Rivera-Brugués, Núria (Author) , Moog, Ute (Author) , Lorenz-Depiereux, Bettina (Author) , Eck, Sebastian (Author) , Hempel, Maja (Author) , Wagenstaller, Janine (Author) , Gawthrope, Alex (Author) , Monaco, Anthony P. (Author) , Bonin, Michael (Author) , Riess, Olaf (Author) , Wohlleber, Eva (Author) , Illig, Thomas (Author) , Bezzina, Connie R. (Author) , Franke, Andre (Author) , Spranger, Stephanie (Author) , Villavicencio-Lorini, Pablo (Author) , Seifert, Wenke (Author) , Rosenfeld, Jochen (Author) , Klopocki, Eva (Author) , Rappold, Gudrun (Author) , Strom, Tim M. (Author)
Format: Article (Journal)
Language:English
Published: [November 2010]
In: Human mutation
Year: 2010, Volume: 31, Issue: 11, Pages: E1851-E1860
ISSN:1098-1004
DOI:10.1002/humu.21362
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/humu.21362
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/humu.21362
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Author Notes:Denise Horn, Johannes Kapeller, Núria Rivera-Brugués, Ute Moog, Bettina Lorenz-Depiereux, Sebastian Eck, Maja Hempel, Janine Wagenstaller, Alex Gawthrope, Anthony P. Monaco, Michael Bonin, Olaf Riess, Eva Wohlleber, Thomas Illig, Connie R. Bezzina, Andre Franke, Stephanie Spranger, Pablo Villavicencio-Lorini, Wenke Seifert, Jochen Rosenfeld, Eva Klopocki, Gudrun A. Rappold, and Tim M. Strom
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Summary:Mental retardation affects 2-3% of the population and shows a high heritability. Neurodevelopmental disorders that include pronounced impairment in language and speech skills occur less frequently. For most cases, the molecular basis of mental retardation with or without speech and language disorder is unknown due to the heterogeneity of underlying genetic factors. We have used molecular karyotyping on 1523 patients with mental retardation to detect copy number variations (CNVs) including deletions or duplications. These studies revealed three heterozygous overlapping deletions solely affecting the forkhead box P1 (FOXP1) gene. All three patients had moderate mental retardation and significant language and speech deficits. Since our results are consistent with a de novo occurrence of these deletions, we considered them as causal although we detected a single large deletion including FOXP1 and additional genes in 4104 ancestrally matched controls. These findings are of interest with regard to the structural and functional relationship between FOXP1 and FOXP2. Mutations in FOXP2 have been previously related to monogenic cases of developmental verbal dyspraxia. Both FOXP1 and FOXP2 are expressed in songbird and human brain regions that are important for the developmental processes that culminate in speech and language. ©2010 Wiley-Liss, Inc.
Item Description:Published: 16 September 2010
Gesehen am 17.04.2023
Physical Description:Online Resource
ISSN:1098-1004
DOI:10.1002/humu.21362

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