Cover Image

Deuteration distribution estimation with improved sequence coverage for HX/MS experiments

Time-resolved hydrogen exchange (HX) followed by mass spectrometry (MS) is a key technology for studying protein structure, dynamics and interactions. HX experiments deliver a time-dependent distribution of deuteration levels of peptide sequences of the protein of interest. The robust and complete e...

Full description

Saved in:
Bibliographic Details
Main Authors: Lou, Xinghua (Author) , Kirchner, Marc (Author) , Renard, Bernhard Y. (Author) , Köthe, Ullrich (Author) , Boppel, Sebastian (Author) , Graf, Christian (Author) , Lee, Chung-Tien (Author) , Steen, Judith A. J. (Author) , Steen, Hanno (Author) , Mayer, Matthias P. (Author) , Hamprecht, Fred (Author)
Format: Article (Journal)
Language:English
Published: May 3, 2010
In: Bioinformatics
Year: 2010, Volume: 26, Issue: 12, Pages: 1535-1541
ISSN:1367-4811
DOI:10.1093/bioinformatics/btq165
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1093/bioinformatics/btq165
Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/bioinformatics/article/26/12/1535/281316?login=true
Get full text
Author Notes:Xinghua Lou, Marc Kirchner, Bernhard Y. Renard, Ullrich Köthe, Sebastian Boppel, Christian Graf, Chung-Tien Lee, Judith A.J. Steen, Hanno Steen, Matthias P. Mayer and Fred A. Hamprecht

MARC

LEADER 00000caa a2200000 c 4500
001 1843045656
003 DE-627
005 20230710143503.0
007 cr uuu---uuuuu
008 230418s2010 xx |||||o 00| ||eng c
024 7 |a 10.1093/bioinformatics/btq165  |2 doi 
035 |a (DE-627)1843045656 
035 |a (DE-599)KXP1843045656 
035 |a (OCoLC)1389806589 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 32  |2 sdnb 
100 1 |a Lou, Xinghua  |e VerfasserIn  |0 (DE-588)1019421061  |0 (DE-627)685036618  |0 (DE-576)358020808  |4 aut 
245 1 0 |a Deuteration distribution estimation with improved sequence coverage for HX/MS experiments  |c Xinghua Lou, Marc Kirchner, Bernhard Y. Renard, Ullrich Köthe, Sebastian Boppel, Christian Graf, Chung-Tien Lee, Judith A.J. Steen, Hanno Steen, Matthias P. Mayer and Fred A. Hamprecht 
264 1 |c May 3, 2010 
300 |a 7 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 18.04.2023 
520 |a Time-resolved hydrogen exchange (HX) followed by mass spectrometry (MS) is a key technology for studying protein structure, dynamics and interactions. HX experiments deliver a time-dependent distribution of deuteration levels of peptide sequences of the protein of interest. The robust and complete estimation of this distribution for as many peptide fragments as possible is instrumental to understanding dynamic protein-level HX behavior. Currently, this data interpretation step still is a bottleneck in the overall HX/MS workflow. 
700 1 |a Kirchner, Marc  |e VerfasserIn  |4 aut 
700 1 |a Renard, Bernhard Y.  |e VerfasserIn  |4 aut 
700 1 |a Köthe, Ullrich  |e VerfasserIn  |0 (DE-588)123963435  |0 (DE-627)594480884  |0 (DE-576)304484520  |4 aut 
700 1 |a Boppel, Sebastian  |e VerfasserIn  |4 aut 
700 1 |a Graf, Christian  |e VerfasserIn  |4 aut 
700 1 |a Lee, Chung-Tien  |e VerfasserIn  |4 aut 
700 1 |a Steen, Judith A. J.  |e VerfasserIn  |4 aut 
700 1 |a Steen, Hanno  |e VerfasserIn  |4 aut 
700 1 |a Mayer, Matthias P.  |d 1960-  |e VerfasserIn  |0 (DE-588)1060239752  |0 (DE-627)799340510  |0 (DE-576)167058827  |4 aut 
700 1 |a Hamprecht, Fred  |e VerfasserIn  |0 (DE-588)1020505605  |0 (DE-627)691240280  |0 (DE-576)360605516  |4 aut 
773 0 8 |i Enthalten in  |t Bioinformatics  |d Oxford : Oxford Univ. Press, 1998  |g 26(2010), 12, Seite 1535-1541  |h Online-Ressource  |w (DE-627)266884857  |w (DE-600)1468345-3  |w (DE-576)079420133  |x 1367-4811  |7 nnas  |a Deuteration distribution estimation with improved sequence coverage for HX/MS experiments 
773 1 8 |g volume:26  |g year:2010  |g number:12  |g pages:1535-1541  |g extent:7  |a Deuteration distribution estimation with improved sequence coverage for HX/MS experiments 
856 4 0 |u https://doi.org/10.1093/bioinformatics/btq165  |x Resolving-System  |x Verlag  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://academic.oup.com/bioinformatics/article/26/12/1535/281316?login=true  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20230418 
993 |a Article 
994 |a 2010 
998 |g 1020505605  |a Hamprecht, Fred  |m 1020505605:Hamprecht, Fred  |d 700000  |d 708000  |e 700000PH1020505605  |e 708000PH1020505605  |k 0/700000/  |k 1/700000/708000/  |p 11  |y j 
998 |g 1060239752  |a Mayer, Matthias P.  |m 1060239752:Mayer, Matthias P.  |d 700000  |d 706000  |e 700000PM1060239752  |e 706000PM1060239752  |k 0/700000/  |k 1/700000/706000/  |p 10 
998 |g 123963435  |a Köthe, Ullrich  |m 123963435:Köthe, Ullrich  |d 700000  |d 708000  |e 700000PK123963435  |e 708000PK123963435  |k 0/700000/  |k 1/700000/708000/  |p 4 
998 |g 1019421061  |a Lou, Xinghua  |m 1019421061:Lou, Xinghua  |d 110000  |e 110000PL1019421061  |k 0/110000/  |p 1  |x j 
999 |a KXP-PPN1843045656  |e 4310863124 
BIB |a Y 
SER |a journal 
JSO |a {"physDesc":[{"extent":"7 S."}],"name":{"displayForm":["Xinghua Lou, Marc Kirchner, Bernhard Y. Renard, Ullrich Köthe, Sebastian Boppel, Christian Graf, Chung-Tien Lee, Judith A.J. Steen, Hanno Steen, Matthias P. Mayer and Fred A. Hamprecht"]},"recId":"1843045656","id":{"eki":["1843045656"],"doi":["10.1093/bioinformatics/btq165"]},"relHost":[{"id":{"zdb":["1468345-3"],"issn":["1367-4811"],"eki":["266884857"]},"pubHistory":["14.1998 -"],"recId":"266884857","physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"note":["Gesehen am 26.07.2023","Fortsetzung der Druck-Ausgabe"],"origin":[{"publisherPlace":"Oxford","dateIssuedDisp":"1998-","dateIssuedKey":"1998","publisher":"Oxford Univ. Press"}],"title":[{"title_sort":"Bioinformatics","title":"Bioinformatics"}],"titleAlt":[{"title":"Bioinformatics online"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"issue":"12","extent":"7","volume":"26","year":"2010","text":"26(2010), 12, Seite 1535-1541","pages":"1535-1541"},"disp":"Deuteration distribution estimation with improved sequence coverage for HX/MS experimentsBioinformatics"}],"person":[{"display":"Lou, Xinghua","family":"Lou","given":"Xinghua","role":"aut"},{"role":"aut","given":"Marc","display":"Kirchner, Marc","family":"Kirchner"},{"family":"Renard","display":"Renard, Bernhard Y.","role":"aut","given":"Bernhard Y."},{"role":"aut","given":"Ullrich","display":"Köthe, Ullrich","family":"Köthe"},{"given":"Sebastian","role":"aut","display":"Boppel, Sebastian","family":"Boppel"},{"role":"aut","given":"Christian","display":"Graf, Christian","family":"Graf"},{"display":"Lee, Chung-Tien","family":"Lee","given":"Chung-Tien","role":"aut"},{"given":"Judith A. J.","role":"aut","display":"Steen, Judith A. J.","family":"Steen"},{"given":"Hanno","role":"aut","family":"Steen","display":"Steen, Hanno"},{"display":"Mayer, Matthias P.","family":"Mayer","given":"Matthias P.","role":"aut"},{"family":"Hamprecht","display":"Hamprecht, Fred","given":"Fred","role":"aut"}],"title":[{"title_sort":"Deuteration distribution estimation with improved sequence coverage for HX/MS experiments","title":"Deuteration distribution estimation with improved sequence coverage for HX/MS experiments"}],"note":["Gesehen am 18.04.2023"],"origin":[{"dateIssuedKey":"2010","dateIssuedDisp":"May 3, 2010"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"]} 
SRT |a LOUXINGHUADEUTERATIO3201 

Similar Items