Her2 overexpression is a rare event in anorectal melanoma
Anorectal melanomas (AMs) are very rare and highly malignant tumors that are often diagnosed in advanced stages. After the differentiation between cutaneous melanoma (CM) and AM on the molecular level based on the presence of BRAF mutations, further modes of differentiation opened up, such as the re...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[October 2010]
|
| In: |
Melanoma research
Year: 2010, Jahrgang: 20, Heft: 5, Pages: 431-434 |
| ISSN: | 1473-5636 |
| DOI: | 10.1097/CMR.0b013e32833ab159 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/CMR.0b013e32833ab159 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/melanomaresearch/Fulltext/2010/10000/Her2_overexpression_is_a_rare_event_in_anorectal.10.aspx 
|
| Verfasserangaben: | Burkhard Maria Helmke, Tina Zahel, Marco Breinig, Peter Schirmacher, Sebastian Aulmann and Michael André Kern |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1843124173 | ||
| 003 | DE-627 | ||
| 005 | 20230710143336.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230419s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1097/CMR.0b013e32833ab159 |2 doi | |
| 035 | |a (DE-627)1843124173 | ||
| 035 | |a (DE-599)KXP1843124173 | ||
| 035 | |a (OCoLC)1389806632 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Helmke, Burkhard Maria |d 1964- |e VerfasserIn |0 (DE-588)124280269 |0 (DE-627)08575806X |0 (DE-576)294100083 |4 aut | |
| 245 | 1 | 0 | |a Her2 overexpression is a rare event in anorectal melanoma |c Burkhard Maria Helmke, Tina Zahel, Marco Breinig, Peter Schirmacher, Sebastian Aulmann and Michael André Kern |
| 264 | 1 | |c [October 2010] | |
| 300 | |b Illustrationen | ||
| 300 | |a 4 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 19.04.2023 | ||
| 520 | |a Anorectal melanomas (AMs) are very rare and highly malignant tumors that are often diagnosed in advanced stages. After the differentiation between cutaneous melanoma (CM) and AM on the molecular level based on the presence of BRAF mutations, further modes of differentiation opened up, such as the recently discovered immunohistologically relevant protein deleted in malignant brain tumors 1 (DMBT1). Over the past several years, increasingly specific therapies have been developed on the basis of new therapy principles. Tyrosin kinase receptors such as Her2 and EGFR have been awarded a large role in this context. The goal of this study was to examine AMs for a possible expression or overexpression of these markers. Expression analyses of Her2 and EGFR were performed immunohistologically on 25 primary AMs. An overexpression of Her2 (score: 3+) was found in one AM from a 68-year-old female patient among these samples. In contrast, EGFR expression was not found in any of the AMs. The results presented here show that isolated cases of AM may benefit from an additive Her2-directed therapy, as the overexpression of Her2 was found in one of our AM patients. | ||
| 700 | 1 | |a Zahel, Tina |d 1984- |e VerfasserIn |0 (DE-588)1041698135 |0 (DE-627)767481739 |0 (DE-576)393410463 |4 aut | |
| 700 | 1 | |a Breinig, Marco |e VerfasserIn |0 (DE-588)141226749 |0 (DE-627)703917579 |0 (DE-576)322839637 |4 aut | |
| 700 | 1 | |a Schirmacher, Peter |d 1961- |e VerfasserIn |0 (DE-588)1020440112 |0 (DE-627)691221197 |0 (DE-576)360427448 |4 aut | |
| 700 | 1 | |a Aulmann, Sebastian |d 1973- |e VerfasserIn |0 (DE-588)124520197 |0 (DE-627)363393021 |0 (DE-576)294211519 |4 aut | |
| 700 | 1 | |a Kern, Michael A. |d 1968- |e VerfasserIn |0 (DE-588)120548283 |0 (DE-627)080740987 |0 (DE-576)292272545 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Melanoma research |d Hagerstown, Md. : Lippincott Williams & Wilkins, 1991 |g 20(2010), 5 vom: Okt., Seite 431-434 |h Online-Ressource |w (DE-627)324822308 |w (DE-600)2030780-9 |w (DE-576)09629065X |x 1473-5636 |7 nnas |a Her2 overexpression is a rare event in anorectal melanoma |
| 773 | 1 | 8 | |g volume:20 |g year:2010 |g number:5 |g month:10 |g pages:431-434 |g extent:4 |a Her2 overexpression is a rare event in anorectal melanoma |
| 856 | 4 | 0 | |u https://doi.org/10.1097/CMR.0b013e32833ab159 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://journals.lww.com/melanomaresearch/Fulltext/2010/10000/Her2_overexpression_is_a_rare_event_in_anorectal.10.aspx |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230419 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 120548283 |a Kern, Michael A. |m 120548283:Kern, Michael A. |d 910000 |d 912000 |e 910000PK120548283 |e 912000PK120548283 |k 0/910000/ |k 1/910000/912000/ |p 6 |y j | ||
| 998 | |g 124520197 |a Aulmann, Sebastian |m 124520197:Aulmann, Sebastian |d 50000 |e 50000PA124520197 |k 0/50000/ |p 5 | ||
| 998 | |g 1020440112 |a Schirmacher, Peter |m 1020440112:Schirmacher, Peter |d 910000 |d 912000 |e 910000PS1020440112 |e 912000PS1020440112 |k 0/910000/ |k 1/910000/912000/ |p 4 | ||
| 998 | |g 141226749 |a Breinig, Marco |m 141226749:Breinig, Marco |d 910000 |d 912000 |e 910000PB141226749 |e 912000PB141226749 |k 0/910000/ |k 1/910000/912000/ |p 3 | ||
| 998 | |g 1041698135 |a Zahel, Tina |m 1041698135:Zahel, Tina |d 910000 |d 912000 |e 910000PZ1041698135 |e 912000PZ1041698135 |k 0/910000/ |k 1/910000/912000/ |p 2 | ||
| 998 | |g 124280269 |a Helmke, Burkhard Maria |m 124280269:Helmke, Burkhard Maria |d 50000 |e 50000PH124280269 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1843124173 |e 4311175981 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Her2 overexpression is a rare event in anorectal melanoma","title":"Her2 overexpression is a rare event in anorectal melanoma"}],"person":[{"role":"aut","display":"Helmke, Burkhard Maria","given":"Burkhard Maria","family":"Helmke"},{"given":"Tina","family":"Zahel","display":"Zahel, Tina","role":"aut"},{"role":"aut","display":"Breinig, Marco","family":"Breinig","given":"Marco"},{"role":"aut","display":"Schirmacher, Peter","family":"Schirmacher","given":"Peter"},{"role":"aut","given":"Sebastian","family":"Aulmann","display":"Aulmann, Sebastian"},{"role":"aut","given":"Michael A.","family":"Kern","display":"Kern, Michael A."}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"[October 2010]","dateIssuedKey":"2010"}],"note":["Gesehen am 19.04.2023"],"id":{"eki":["1843124173"],"doi":["10.1097/CMR.0b013e32833ab159"]},"recId":"1843124173","relHost":[{"id":{"zdb":["2030780-9"],"issn":["1473-5636"],"eki":["324822308"]},"recId":"324822308","language":["eng"],"part":{"issue":"5","year":"2010","text":"20(2010), 5 vom: Okt., Seite 431-434","pages":"431-434","volume":"20","extent":"4"},"disp":"Her2 overexpression is a rare event in anorectal melanomaMelanoma research","physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedDisp":"1991-","publisher":"Lippincott Williams & Wilkins ; Ovid","publisherPlace":"Hagerstown, Md. ; [Erscheinungsort nicht ermittelbar]","dateIssuedKey":"1991"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.1991 -"],"title":[{"title_sort":"Melanoma research","subtitle":"an international journal for rapid communication of basic and clinical research in melanoma","title":"Melanoma research"}],"note":["Gesehen am 28.05.19"]}],"name":{"displayForm":["Burkhard Maria Helmke, Tina Zahel, Marco Breinig, Peter Schirmacher, Sebastian Aulmann and Michael André Kern"]},"physDesc":[{"noteIll":"Illustrationen","extent":"4 S."}],"language":["eng"]} | ||
| SRT | |a HELMKEBURKHER2OVEREX2010 | ||