Development of High-Performance pyrimidine nucleoside and oligonucleotide diarylethene photoswitches
Nucleosidic and oligonucleotidic diarylethenes (DAEs) are an emerging class of photochromes with high application potential. However, their further development is hampered by the poor understanding of how the chemical structure modulates the photochromic properties. Here we synthesized 26 systematic...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2021
|
| In: |
Angewandte Chemie. International edition
Year: 2021, Jahrgang: 60, Heft: 15, Pages: 8164-8173 |
| ISSN: | 1521-3773 |
| DOI: | 10.1002/anie.202014878 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/anie.202014878 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202014878 
|
| Verfasserangaben: | Theresa Kolmar, Simon M. Büllmann, Christopher Sarter, Katharina Höfer, and Andres Jäschke |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1843299534 | ||
| 003 | DE-627 | ||
| 005 | 20250112235139.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230420s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/anie.202014878 |2 doi | |
| 035 | |a (DE-627)1843299534 | ||
| 035 | |a (DE-599)KXP1843299534 | ||
| 035 | |a (OCoLC)1389537877 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Kolmar, Theresa |d 1992- |e VerfasserIn |0 (DE-588)1190305445 |0 (DE-627)1669003485 |4 aut | |
| 245 | 1 | 0 | |a Development of High-Performance pyrimidine nucleoside and oligonucleotide diarylethene photoswitches |c Theresa Kolmar, Simon M. Büllmann, Christopher Sarter, Katharina Höfer, and Andres Jäschke |
| 264 | 1 | |c 2021 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 20.04.2023 | ||
| 520 | |a Nucleosidic and oligonucleotidic diarylethenes (DAEs) are an emerging class of photochromes with high application potential. However, their further development is hampered by the poor understanding of how the chemical structure modulates the photochromic properties. Here we synthesized 26 systematically varied deoxyuridine- and deoxycytidine-derived DAEs and analyzed reaction quantum yields, composition of the photostationary states, thermal and photochemical stability, and reversibility. This analysis identified two high-performance photoswitches with near-quantitative, fully reversible back-and-forth switching and no detectable thermal or photochemical deterioration. When incorporated into an oligonucleotide with the sequence of a promotor, the nucleotides maintained their photochromism and allowed the modulation of the transcription activity of T7 RNA polymerase with an up to 2.4-fold turn-off factor, demonstrating the potential for optochemical control of biological processes. | ||
| 650 | 4 | |a diarylethenes | |
| 650 | 4 | |a in vitro transcription | |
| 650 | 4 | |a nucleic acids | |
| 650 | 4 | |a photochromism | |
| 650 | 4 | |a photoresponsive DNA | |
| 700 | 1 | |a Büllmann, Simon |d 1992- |e VerfasserIn |0 (DE-588)1199059463 |0 (DE-627)1681428660 |4 aut | |
| 700 | 1 | |a Sarter, Christopher |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Höfer, Katharina |e VerfasserIn |0 (DE-588)1064553788 |0 (DE-627)813191327 |0 (DE-576)423961594 |4 aut | |
| 700 | 1 | |a Jäschke, Andres |d 1962- |e VerfasserIn |0 (DE-588)1025112261 |0 (DE-627)751682756 |0 (DE-576)170797481 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Angewandte Chemie. International edition |d Weinheim : Wiley-VCH, 1998 |g 60(2021), 15, Seite 8164-8173 |h Online-Ressource |w (DE-627)320497879 |w (DE-600)2011836-3 |w (DE-576)111552060 |x 1521-3773 |7 nnas |a Development of High-Performance pyrimidine nucleoside and oligonucleotide diarylethene photoswitches |
| 773 | 1 | 8 | |g volume:60 |g year:2021 |g number:15 |g pages:8164-8173 |g extent:10 |a Development of High-Performance pyrimidine nucleoside and oligonucleotide diarylethene photoswitches |
| 856 | 4 | 0 | |u https://doi.org/10.1002/anie.202014878 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202014878 |x Verlag |z kostenfrei |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20230420 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 1025112261 |a Jäschke, Andres |m 1025112261:Jäschke, Andres |d 160000 |d 160100 |e 160000PJ1025112261 |e 160100PJ1025112261 |k 0/160000/ |k 1/160000/160100/ |p 5 |y j | ||
| 998 | |g 1199059463 |a Büllmann, Simon |m 1199059463:Büllmann, Simon |d 160000 |d 160100 |e 160000PB1199059463 |e 160100PB1199059463 |k 0/160000/ |k 1/160000/160100/ |p 2 | ||
| 998 | |g 1190305445 |a Kolmar, Theresa |m 1190305445:Kolmar, Theresa |d 160000 |d 160100 |e 160000PK1190305445 |e 160100PK1190305445 |k 0/160000/ |k 1/160000/160100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1843299534 |e 4312178852 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Theresa Kolmar, Simon M. Büllmann, Christopher Sarter, Katharina Höfer, and Andres Jäschke"]},"note":["Gesehen am 20.04.2023"],"recId":"1843299534","language":["eng"],"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"2021"}],"id":{"doi":["10.1002/anie.202014878"],"eki":["1843299534"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title_sort":"Development of High-Performance pyrimidine nucleoside and oligonucleotide diarylethene photoswitches","title":"Development of High-Performance pyrimidine nucleoside and oligonucleotide diarylethene photoswitches"}],"relHost":[{"titleAlt":[{"title":"Angewandte Chemie / International edition"}],"disp":"Development of High-Performance pyrimidine nucleoside and oligonucleotide diarylethene photoswitchesAngewandte Chemie. International edition","part":{"pages":"8164-8173","issue":"15","extent":"10","volume":"60","year":"2021","text":"60(2021), 15, Seite 8164-8173"},"id":{"issn":["1521-3773"],"eki":["320497879"],"doi":["10.1002/(ISSN)1521-3773"],"zdb":["2011836-3"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"subtitle":"a journal of the Gesellschaft Deutscher Chemiker","partname":"International edition","title":"Angewandte Chemie","title_sort":"Angewandte Chemie"}],"physDesc":[{"extent":"Online-Ressource"}],"corporate":[{"role":"isb","display":"Gesellschaft Deutscher Chemiker"}],"recId":"320497879","language":["eng"],"note":["Gesehen am 20.12.2022","Fortsetzung der Druck-Ausgabe"],"origin":[{"publisherPlace":"Weinheim","publisher":"Wiley-VCH","dateIssuedDisp":"1998-","dateIssuedKey":"1998"}],"pubHistory":["37.1998 -"]}],"physDesc":[{"extent":"10 S."}],"person":[{"given":"Theresa","role":"aut","display":"Kolmar, Theresa","family":"Kolmar"},{"role":"aut","given":"Simon","family":"Büllmann","display":"Büllmann, Simon"},{"given":"Christopher","role":"aut","display":"Sarter, Christopher","family":"Sarter"},{"family":"Höfer","display":"Höfer, Katharina","role":"aut","given":"Katharina"},{"role":"aut","given":"Andres","family":"Jäschke","display":"Jäschke, Andres"}]} | ||
| SRT | |a KOLMARTHERDEVELOPMEN2021 | ||