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Standardized airway wall thickness Pi10 from routine CT scans of COPD patients as imaging biomarker for disease severity, lung function decline, and mortality

Background:Chest computed tomography (CT) is increasingly used for phenotyping and monitoring of patients with COPD. The aim of this work was to evaluate the association of Pi10 as a measure of standardized airway wall thickness on CT with exacerbations, mortality, and response to triple therapy.Met...

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Main Authors: Kahnert, Kathrin (Author) , Jörres, Rudolf (Author) , Kauczor, Hans-Ulrich (Author) , Alter, Peter (Author) , Trudzinski, Franziska (Author) , Herth, Felix (Author) , Jobst, Bertram (Author) , Weinheimer, Oliver (Author) , Nauck, Sebastian (Author) , Mertsch, Pontus Jeremias Paul (Author) , Kauffmann-Guerrero, Diego (Author) , Behr, Jürgen (Author) , Bals, Robert (Author) , Watz, Henrik (Author) , Rabe, Klaus F. (Author) , Welte, Tobias (Author) , Vogelmeier, Claus F. (Author) , Biederer, Jürgen (Author)
Format: Article (Journal)
Language:English
Published: 2023
In: Therapeutic advances in respiratory disease
Year: 2023, Volume: 17, Pages: 1-14
ISSN:1753-4666
DOI:10.1177/17534666221148663
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1177/17534666221148663
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Author Notes:Kathrin Kahnert, Rudolf A. Jörres, Hans-Ulrich Kauczor, Peter Alter, Franziska C. Trudzinski, Felix Herth, Bertram Jobst, Oliver Weinheimer, Sebastian Nauck, Pontus Mertsch, Diego Kauffmann-Guerrero, Jürgen Behr, Robert Bals, Henrik Watz, Klaus F. Rabe, Tobias Welte, Claus F. Vogelmeier, and Jürgen Biederer
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Summary:Background:Chest computed tomography (CT) is increasingly used for phenotyping and monitoring of patients with COPD. The aim of this work was to evaluate the association of Pi10 as a measure of standardized airway wall thickness on CT with exacerbations, mortality, and response to triple therapy.Methods:Patients of GOLD grades 1?4 of the COSYCONET cohort with prospective CT scans were included. Pi10 was automatically computed and analyzed for its relationship to COPD severity, comorbidities, lung function, respiratory therapy, and mortality over a 6-year period, using univariate and multivariate comparisons.Results:We included n?=?433 patients (61%male). Pi10 was dependent on both GOLD grades 1?4 (p?=?0.009) and GOLD groups A?D (p?=?0.008); it was particularly elevated in group D, and ROC analysis yielded a cut-off of 0.26?cm. Higher Pi10 was associated to lower FEV1 % predicted and higher RV/TLC, moreover the annual changes of lung function parameters (p?
Item Description:Gesehen am 21.04.2023
Physical Description:Online Resource
ISSN:1753-4666
DOI:10.1177/17534666221148663

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