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Morphological and mitochondrial changes in murine choroid plexus epithelial cells during healthy aging

Choroid plexuses (ChPs) are intraventricular structures mainly composed by specialized epithelial cells interconnected by tight junctions that establish the blood-cerebrospinal fluid (CSF) barrier. ChPs are essential to produce CSF and transport solutes from and into the brain. Deterioration of ChP...

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Main Authors: Scarpetta, Valentina (Author) , Torres, Felipe Bodaleo (Author) , Salio, Chiara (Author) , Agarwal, Amit (Author) , Sassoè-Pognetto, Marco (Author) , Patrizi, Annarita (Author)
Format: Article (Journal)
Language:English
Published: 14 March 2023
In: Fluids and barriers of the CNS
Year: 2023, Volume: 20, Pages: 1-16
ISSN:2045-8118
DOI:10.1186/s12987-023-00420-9
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12987-023-00420-9
Verlag, kostenfrei, Volltext: https://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-023-00420-9
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Author Notes:Valentina Scarpetta, Felipe Bodaleo, Chiara Salio, Amit Agarwal, Marco Sassoè-Pognetto and Annarita Patrizi
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Summary:Choroid plexuses (ChPs) are intraventricular structures mainly composed by specialized epithelial cells interconnected by tight junctions that establish the blood-cerebrospinal fluid (CSF) barrier. ChPs are essential to produce CSF and transport solutes from and into the brain. Deterioration of ChP function and morphology has been correlated to worsening of neurodegenerative disorders. We here map morpho-functional changes in the ChP epithelial cells during healthy aging, starting from young adult to 2-years old mice.
Item Description:Gesehen am 30.11.2023
Physical Description:Online Resource
ISSN:2045-8118
DOI:10.1186/s12987-023-00420-9

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