Patterns of antibody binding to aquaporin-4 isoforms in neuromyelitis optica
Neuromyelitis optica (NMO), a severe demyelinating disease, represents itself with optic neuritis and longitudinally extensive transverse myelitis. Serum NMO-IgG autoantibodies (Abs), a specific finding in NMO patients, target the water channel protein aquaporin-4 (AQP4), which is expressed as a lon...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 5, 2010
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| In: |
PLOS ONE
Year: 2010, Jahrgang: 5, Heft: 5, Pages: 1-7 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0010455 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pone.0010455 Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010455 
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| Verfasserangaben: | Simone Mader, Andreas Lutterotti, Franziska Di Pauli, Bettina Kuenz, Kathrin Schanda, Fahmy Aboul-Enein, Michael Khalil, Maria K. Storch, Sven Jarius, Wolfgang Kristoferitsch, Thomas Berger, Markus Reindl |
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| 520 | |a Neuromyelitis optica (NMO), a severe demyelinating disease, represents itself with optic neuritis and longitudinally extensive transverse myelitis. Serum NMO-IgG autoantibodies (Abs), a specific finding in NMO patients, target the water channel protein aquaporin-4 (AQP4), which is expressed as a long (M-1) or a short (M-23) isoform. | ||
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