Buchumschlag

Revana: a comprehensive tool for regulatory variant analysis and visualization of cancer genomes

As non-coding driver mutations move more into the focus of cancer research, a comprehensive and easy-to-use software solution for regulatory variant analysis and data visualization is highly relevant. The interpretation of regulatory variants in large tumor genome cohorts requires specialized analys...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Ulrich, Elias (VerfasserIn) , Pfister, Stefan (VerfasserIn) , Jäger, Natalie (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: January 2023
In: Bioinformatics
Year: 2023, Jahrgang: 39, Heft: 1, Pages: 1-3
ISSN:1367-4811
DOI:10.1093/bioinformatics/btac831
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1093/bioinformatics/btac831
Volltext
Verfasserangaben:Elias Ulrich, Stefan M. Pfister and Natalie Jäger

MARC

LEADER 00000caa a2200000 c 4500
001 1843545144
003 DE-627
005 20230706211944.0
007 cr uuu---uuuuu
008 230425s2023 xx |||||o 00| ||eng c
024 7 |a 10.1093/bioinformatics/btac831  |2 doi 
035 |a (DE-627)1843545144 
035 |a (DE-599)KXP1843545144 
035 |a (OCoLC)1389530445 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Ulrich, Elias  |d 1997-  |e VerfasserIn  |0 (DE-588)1286987407  |0 (DE-627)1843546787  |4 aut 
245 1 0 |a Revana  |b a comprehensive tool for regulatory variant analysis and visualization of cancer genomes  |c Elias Ulrich, Stefan M. Pfister and Natalie Jäger 
264 1 |c January 2023 
300 |a 3 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 25.04.2023 
500 |a Published: 28 December 2022 
520 |a As non-coding driver mutations move more into the focus of cancer research, a comprehensive and easy-to-use software solution for regulatory variant analysis and data visualization is highly relevant. The interpretation of regulatory variants in large tumor genome cohorts requires specialized analysis and visualization of multiple layers of data, including for example breakpoints of structural variants, enhancer elements and additional available gene locus annotation, in the context of changes in gene expression. We introduce a user-friendly tool, Revana (REgulatory Variant ANAlysis), that can aggregate and visually represent regulatory variants from cancer genomes in a gene-centric manner. It requires whole-genome and RNA sequencing data of a cohort of tumor samples and creates interactive HTML reports summarizing the most important regulatory events.Revana is implemented in R and JavaScript. It is available for download as an R package under <https://github.com/KiTZ-Heidelberg/revana>. Sample results can be viewed under <https://github.com/KiTZ-Heidelberg/revana-demo-report> and a short walkthrough is available under <https://github.com/KiTZ-Heidelberg/revana-demo-data>.Supplementary data are available at Bioinformatics online. 
700 1 |a Pfister, Stefan  |d 1974-  |e VerfasserIn  |0 (DE-588)123850215  |0 (DE-627)706450930  |0 (DE-576)293908400  |4 aut 
700 1 |a Jäger, Natalie  |e VerfasserIn  |0 (DE-588)1057941662  |0 (DE-627)795556195  |0 (DE-576)413944638  |4 aut 
773 0 8 |i Enthalten in  |t Bioinformatics  |d Oxford : Oxford Univ. Press, 1998  |g 39(2023), 1, Artikel-ID btac831, Seite 1-3  |h Online-Ressource  |w (DE-627)266884857  |w (DE-600)1468345-3  |w (DE-576)079420133  |x 1367-4811  |7 nnas  |a Revana a comprehensive tool for regulatory variant analysis and visualization of cancer genomes 
773 1 8 |g volume:39  |g year:2023  |g number:1  |g elocationid:btac831  |g pages:1-3  |g extent:3  |a Revana a comprehensive tool for regulatory variant analysis and visualization of cancer genomes 
856 4 0 |u https://doi.org/10.1093/bioinformatics/btac831  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20230425 
993 |a Article 
994 |a 2023 
998 |g 1057941662  |a Jäger, Natalie  |m 1057941662:Jäger, Natalie  |d 50000  |e 50000PJ1057941662  |k 0/50000/  |p 3  |y j 
998 |g 123850215  |a Pfister, Stefan  |m 123850215:Pfister, Stefan  |d 910000  |d 910500  |e 910000PP123850215  |e 910500PP123850215  |k 0/910000/  |k 1/910000/910500/  |p 2 
998 |g 1286987407  |a Ulrich, Elias  |m 1286987407:Ulrich, Elias  |d 50000  |e 50000PU1286987407  |k 0/50000/  |p 1  |x j 
999 |a KXP-PPN1843545144  |e 4314290048 
BIB |a Y 
SER |a journal 
JSO |a {"relHost":[{"title":[{"title":"Bioinformatics","title_sort":"Bioinformatics"}],"physDesc":[{"extent":"Online-Ressource"}],"part":{"volume":"39","text":"39(2023), 1, Artikel-ID btac831, Seite 1-3","extent":"3","issue":"1","year":"2023","pages":"1-3"},"language":["eng"],"note":["Gesehen am 26.07.2023","Fortsetzung der Druck-Ausgabe"],"pubHistory":["14.1998 -"],"titleAlt":[{"title":"Bioinformatics online"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"issn":["1367-4811"],"zdb":["1468345-3"],"eki":["266884857"]},"recId":"266884857","origin":[{"publisher":"Oxford Univ. Press","publisherPlace":"Oxford","dateIssuedKey":"1998","dateIssuedDisp":"1998-"}],"disp":"Revana a comprehensive tool for regulatory variant analysis and visualization of cancer genomesBioinformatics"}],"title":[{"subtitle":"a comprehensive tool for regulatory variant analysis and visualization of cancer genomes","title_sort":"Revana","title":"Revana"}],"physDesc":[{"extent":"3 S."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1843545144","id":{"doi":["10.1093/bioinformatics/btac831"],"eki":["1843545144"]},"name":{"displayForm":["Elias Ulrich, Stefan M. Pfister and Natalie Jäger"]},"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"January 2023"}],"language":["eng"],"note":["Gesehen am 25.04.2023","Published: 28 December 2022"],"person":[{"given":"Elias","family":"Ulrich","role":"aut","display":"Ulrich, Elias"},{"given":"Stefan","display":"Pfister, Stefan","role":"aut","family":"Pfister"},{"display":"Jäger, Natalie","role":"aut","family":"Jäger","given":"Natalie"}]} 
SRT |a ULRICHELIAREVANA2023 

Ähnliche Einträge