Buchumschlag

Elucidating the multimodal anticancer mechanism of an organometallic terpyridine platinum(II) N-heterocyclic carbene complex against triple-negative breast cancer In Vitro and In Vivo

Treatment of triple-negative breast cancer (TNBC) has long been a medical challenge because of the lack of effective therapeutic targets. Targeting lipid, carbohydrate, and nucleotide metabolism pathways has recently been proven as a promising option in view of three heterogeneous metabolic-pathway-...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Zhang, Jing-Jing (VerfasserIn) , Xu, Qi-Jie (VerfasserIn) , Schmidt, Claudia (VerfasserIn) , Abu El Maaty, Mohamed A. (VerfasserIn) , Song, Jinglin (VerfasserIn) , Yu, Chunqiu (VerfasserIn) , Zhou, Jun (VerfasserIn) , Han, Kang (VerfasserIn) , Sun, Hao (VerfasserIn) , Casini, Angela (VerfasserIn) , Ott, Ingo (VerfasserIn) , Wölfl, Stefan (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 10 March 2023
In: Journal of medicinal chemistry
Year: 2023, Jahrgang: 66, Heft: 6, Pages: 3995-4008
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.2c01925
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/acs.jmedchem.2c01925
Volltext
Verfasserangaben:Jing-Jing Zhang, Qi-Jie Xu, Claudia Schmidt, Mohamed A. Abu el Maaty, Jinglin Song, Chunqiu Yu, Jun Zhou, Kang Han, Hao Sun, Angela Casini, Ingo Ott, and Stefan Wölfl
Beschreibung
Zusammenfassung:Treatment of triple-negative breast cancer (TNBC) has long been a medical challenge because of the lack of effective therapeutic targets. Targeting lipid, carbohydrate, and nucleotide metabolism pathways has recently been proven as a promising option in view of three heterogeneous metabolic-pathway-based TNBC subtypes. Here, we present a multimodal anticancer platinum(II) complex, named Pt(II)caffeine, with a novel mode of action involving simultaneous mitochondrial damage, inhibition of lipid, carbohydrate, and nucleotide metabolic pathways, and promotion of autophagy. All these biological processes eventually result in a strong suppression of TNBC MDA-MB-231 cell proliferation both in vitro and in vivo. The results indicate that Pt(II)caffeine, influencing cellular metabolism at multiple levels, is a metallodrug with increased potential to overcome the metabolic heterogeneity of TNBC.
Beschreibung:Gesehen am 26.04.2023
Beschreibung:Online Resource
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.2c01925

Ähnliche Einträge