Non-invasive diagnosis of liver diseases by breath analysis using an optimized ion-molecule reaction-mass spectrometry approach: a pilot study
Breath composition is altered in liver diseases. We tested if ion-molecule-reaction mass spectrometry (IMR-MS) combined with a new statistical modality improves the diagnostic accuracy of breath analysis in liver diseases. We analysed 114 molecules in the breath of 126 individuals (healthy controls,...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 Feb 2010
|
| In: |
Biomarkers
Year: 2010, Volume: 15, Issue: 4, Pages: 297-306 |
| ISSN: | 1366-5804 |
| DOI: | 10.3109/13547501003624512 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3109/13547501003624512
|
| Author Notes: | Gunda Millonig, Siegfried Praun, Michael Netzer, Christian Baumgartner, Albert Dornauer, Sebastian Mueller, Johannes Villinger & Wolfgang Vogel |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1843616246 | ||
| 003 | DE-627 | ||
| 005 | 20230710142042.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230426s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3109/13547501003624512 |2 doi | |
| 035 | |a (DE-627)1843616246 | ||
| 035 | |a (DE-599)KXP1843616246 | ||
| 035 | |a (OCoLC)1389806316 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Millonig, Gunda |d 1976- |e VerfasserIn |0 (DE-588)1016233647 |0 (DE-627)705501868 |0 (DE-576)34814282X |4 aut | |
| 245 | 1 | 0 | |a Non-invasive diagnosis of liver diseases by breath analysis using an optimized ion-molecule reaction-mass spectrometry approach |b a pilot study |c Gunda Millonig, Siegfried Praun, Michael Netzer, Christian Baumgartner, Albert Dornauer, Sebastian Mueller, Johannes Villinger & Wolfgang Vogel |
| 264 | 1 | |c 15 Feb 2010 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 26.04.2023 | ||
| 520 | |a Breath composition is altered in liver diseases. We tested if ion-molecule-reaction mass spectrometry (IMR-MS) combined with a new statistical modality improves the diagnostic accuracy of breath analysis in liver diseases. We analysed 114 molecules in the breath of 126 individuals (healthy controls, and patients with non-alcoholic and alcoholic fatty liver disease and liver cirrhosis) by IMR-MS. Characteristic exhalation patterns were identified for each group. Combining two to seven molecules in the new stacked feature ranking model reached a diagnostic accuracy (area under the curve) for individual liver diseases between 0.88 and 0.97. IMR-MS followed by sophisticated statistical analysis is a promising tool for liver diagnostics by breath analysis. | ||
| 650 | 4 | |a Diagnostics | |
| 650 | 4 | |a exhalation | |
| 650 | 4 | |a fatty liver | |
| 650 | 4 | |a foetor hepaticus | |
| 650 | 4 | |a mass spectrometry | |
| 700 | 1 | |a Praun, Siegfried |e VerfasserIn |4 aut | |
| 700 | 1 | |a Netzer, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Baumgartner, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dornauer, Albert |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mueller, Sebastian |e VerfasserIn |0 (DE-588)115640746X |0 (DE-627)1019235071 |0 (DE-576)502163038 |4 aut | |
| 700 | 1 | |a Villinger, Johannes |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vogel, Wolfgang |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biomarkers |d London : Taylor & Francis, 1996 |g 15(2010), 4, Seite 297-306 |h Online-Ressource |w (DE-627)306323885 |w (DE-600)1496523-9 |w (DE-576)273877836 |x 1366-5804 |7 nnas |a Non-invasive diagnosis of liver diseases by breath analysis using an optimized ion-molecule reaction-mass spectrometry approach a pilot study |
| 773 | 1 | 8 | |g volume:15 |g year:2010 |g number:4 |g pages:297-306 |g extent:10 |a Non-invasive diagnosis of liver diseases by breath analysis using an optimized ion-molecule reaction-mass spectrometry approach a pilot study |
| 856 | 4 | 0 | |u https://doi.org/10.3109/13547501003624512 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230426 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 115640746X |a Mueller, Sebastian |m 115640746X:Mueller, Sebastian |d 50000 |e 50000PM115640746X |k 0/50000/ |p 6 | ||
| 998 | |g 1016233647 |a Millonig, Gunda |m 1016233647:Millonig, Gunda |d 50000 |e 50000PM1016233647 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1843616246 |e 4314941227 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"10 S."}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.3109/13547501003624512"],"eki":["1843616246"]},"title":[{"title":"Non-invasive diagnosis of liver diseases by breath analysis using an optimized ion-molecule reaction-mass spectrometry approach","subtitle":"a pilot study","title_sort":"Non-invasive diagnosis of liver diseases by breath analysis using an optimized ion-molecule reaction-mass spectrometry approach"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Biomarkers","title":"Biomarkers","subtitle":"biochemical indicators of exposure, response, and susceptibility"}],"language":["eng"],"note":["Gesehen am 23.09.15"],"disp":"Non-invasive diagnosis of liver diseases by breath analysis using an optimized ion-molecule reaction-mass spectrometry approach a pilot studyBiomarkers","type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"issn":["1366-5804"],"zdb":["1496523-9"],"eki":["306323885"]},"pubHistory":["1.1996 -"],"part":{"extent":"10","year":"2010","volume":"15","text":"15(2010), 4, Seite 297-306","issue":"4","pages":"297-306"},"origin":[{"publisherPlace":"London ; Abingdon","dateIssuedKey":"1996","dateIssuedDisp":"1996-","publisher":"Taylor & Francis ; Informa Healthcare"}],"recId":"306323885"}],"language":["eng"],"person":[{"display":"Millonig, Gunda","role":"aut","family":"Millonig","given":"Gunda"},{"display":"Praun, Siegfried","role":"aut","family":"Praun","given":"Siegfried"},{"role":"aut","display":"Netzer, Michael","given":"Michael","family":"Netzer"},{"role":"aut","display":"Baumgartner, Christian","given":"Christian","family":"Baumgartner"},{"display":"Dornauer, Albert","role":"aut","family":"Dornauer","given":"Albert"},{"family":"Mueller","given":"Sebastian","display":"Mueller, Sebastian","role":"aut"},{"family":"Villinger","given":"Johannes","display":"Villinger, Johannes","role":"aut"},{"given":"Wolfgang","family":"Vogel","role":"aut","display":"Vogel, Wolfgang"}],"origin":[{"dateIssuedDisp":"15 Feb 2010","dateIssuedKey":"2010"}],"recId":"1843616246","name":{"displayForm":["Gunda Millonig, Siegfried Praun, Michael Netzer, Christian Baumgartner, Albert Dornauer, Sebastian Mueller, Johannes Villinger & Wolfgang Vogel"]},"note":["Gesehen am 26.04.2023"]} | ||
| SRT | |a MILLONIGGUNONINVASIV1520 | ||