Plasma iron controls neutrophil production and function
Low plasma iron (hypoferremia) induced by hepcidin is a conserved inflammatory response that protects against infections but inhibits erythropoiesis. How hypoferremia influences leukocytogenesis is unclear. Using proteomic data, we predicted that neutrophil production would be profoundly more iron-d...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
5 October 2022
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| In: |
Science advances
Year: 2022, Volume: 8, Issue: 40, Pages: 1-11 |
| ISSN: | 2375-2548 |
| DOI: | 10.1126/sciadv.abq5384 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/sciadv.abq5384 Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/10.1126/sciadv.abq5384/ 
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| Author Notes: | Joe N. Frost, Sarah K. Wideman, Alexandra E. Preston, Megan R. Teh, Zhichao Ai, Lihui Wang, Amy Cross, Natasha White, Yavuz Yazicioglu, Michael Bonadonna, Alexander J. Clarke, Andrew E. Armitage, Bruno Galy, Irina A. Udalova, Hal Drakesmith |
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| 520 | |a Low plasma iron (hypoferremia) induced by hepcidin is a conserved inflammatory response that protects against infections but inhibits erythropoiesis. How hypoferremia influences leukocytogenesis is unclear. Using proteomic data, we predicted that neutrophil production would be profoundly more iron-demanding than generation of other white blood cell types. ... | ||
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