Soluble CSF interleukin 2 receptor as indicator of neurosarcoidosis
Neurosarcoidosis (NS) represents an important differential diagnosis of multiple sclerosis (MS). However, thus far no reliable laboratory marker of neurosarcoidosis exists. The objective of this study was to evaluate whether cerebrospinal fluid (CSF) levels of soluble interleukin 2 receptor (sIL2-R)...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 June 2010
|
| In: |
Journal of neurology
Year: 2010, Jahrgang: 257, Heft: 11, Pages: 1855-1863 |
| ISSN: | 1432-1459 |
| DOI: | 10.1007/s00415-010-5623-3 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00415-010-5623-3
|
| Verfasserangaben: | Hela-Felicitas Petereit, Dirk Reske, Hayrettin Tumani, Sven Jarius, F. Markus Leweke, Dirk Woitalla, Hans-Walter Pfister, Andrea Rubbert |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1843789728 | ||
| 003 | DE-627 | ||
| 005 | 20240327080246.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230428s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00415-010-5623-3 |2 doi | |
| 035 | |a (DE-627)1843789728 | ||
| 035 | |a (DE-599)KXP1843789728 | ||
| 035 | |a (OCoLC)1389806063 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Petereit, Hela-Felicitas |e VerfasserIn |0 (DE-588)17290272X |0 (DE-627)697830748 |0 (DE-576)133757552 |4 aut | |
| 245 | 1 | 0 | |a Soluble CSF interleukin 2 receptor as indicator of neurosarcoidosis |c Hela-Felicitas Petereit, Dirk Reske, Hayrettin Tumani, Sven Jarius, F. Markus Leweke, Dirk Woitalla, Hans-Walter Pfister, Andrea Rubbert |
| 246 | 3 | 0 | |a two |
| 264 | 1 | |c 17 June 2010 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 28.04.2023 | ||
| 520 | |a Neurosarcoidosis (NS) represents an important differential diagnosis of multiple sclerosis (MS). However, thus far no reliable laboratory marker of neurosarcoidosis exists. The objective of this study was to evaluate whether cerebrospinal fluid (CSF) levels of soluble interleukin 2 receptor (sIL2-R) distinguish NS and other inflammatory disorders of the central nervous system. For this purpose, 139 paired CSF and serum samples from 11 patients with NS, 21 with MS, 10 with CNS vasculitis, 22 with bacterial meningitis, 17 with viral meningitis/encephalitis, seven with neurotuberculosis, and 18 healthy donors were assessed for sIL2-R using an enzyme-linked immunosorbent assay. We found that sIL2-R CSF levels above 150 pg/ml identified untreated NS patients with an overall accuracy of 93% against a group of non-infectious CNS-diseases. Furthermore, an increase in sIL2-R in the CSF was associated with and preceded the outbreak of new neurological symptoms. In conclusion, these findings suggest that sIL2-R measurement in the CSF may be a valuable tool in the diagnosis and follow-up of patients with suspected and proven neurosarcoidosis. | ||
| 650 | 4 | |a Cerebrospinal fluid (CSF) | |
| 650 | 4 | |a Neurosarcoidosis | |
| 650 | 4 | |a Soluble interleukin 2 (sIL2) receptor | |
| 700 | 1 | |a Reske, Dirk |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tumani, Hayrettin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jarius, Sven |e VerfasserIn |0 (DE-588)1054615918 |0 (DE-627)791654818 |0 (DE-576)410367478 |4 aut | |
| 700 | 1 | |a Leweke, F. Markus |e VerfasserIn |0 (DE-588)1052094287 |0 (DE-627)787796859 |0 (DE-576)407845941 |4 aut | |
| 700 | 1 | |a Woitalla, Dirk |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pfister, Hans-Walter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rubbert, Andrea |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neurology |d [Darmstadt] : Steinkopff, 1974 |g 257(2010), 11 vom: Juni, Seite 1855-1863 |h Online-Ressource |w (DE-627)242065155 |w (DE-600)1421299-7 |w (DE-576)065026500 |x 1432-1459 |7 nnas |a Soluble CSF interleukin 2 receptor as indicator of neurosarcoidosis |
| 773 | 1 | 8 | |g volume:257 |g year:2010 |g number:11 |g month:06 |g pages:1855-1863 |g extent:9 |a Soluble CSF interleukin 2 receptor as indicator of neurosarcoidosis |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00415-010-5623-3 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230428 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 1052094287 |a Leweke, F. Markus |m 1052094287:Leweke, F. Markus |d 60000 |e 60000PL1052094287 |k 0/60000/ |p 5 | ||
| 998 | |g 1054615918 |a Jarius, Sven |m 1054615918:Jarius, Sven |d 910000 |d 911100 |e 910000PJ1054615918 |e 911100PJ1054615918 |k 0/910000/ |k 1/910000/911100/ |p 4 | ||
| 999 | |a KXP-PPN1843789728 |e 4315984760 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Hela-Felicitas Petereit, Dirk Reske, Hayrettin Tumani, Sven Jarius, F. Markus Leweke, Dirk Woitalla, Hans-Walter Pfister, Andrea Rubbert"]},"id":{"eki":["1843789728"],"doi":["10.1007/s00415-010-5623-3"]},"origin":[{"dateIssuedDisp":"17 June 2010","dateIssuedKey":"2010"}],"relHost":[{"recId":"242065155","physDesc":[{"extent":"Online-Ressource"}],"disp":"Soluble CSF interleukin 2 receptor as indicator of neurosarcoidosisJournal of neurology","pubHistory":["Volume 207, issue 1 (March 1974)-"],"origin":[{"dateIssuedDisp":"1974-","dateIssuedKey":"1974","publisherPlace":"[Darmstadt] ; Berlin ; Heidelberg [u.a.] ; Darmstadt ; Heidelberg","publisher":"Steinkopff ; Springer ; Steinkopff [u.a.] ; Springer-Medizin-Verl."}],"part":{"issue":"11","extent":"9","text":"257(2010), 11 vom: Juni, Seite 1855-1863","pages":"1855-1863","volume":"257","year":"2010"},"title":[{"title_sort":"Journal of neurology","title":"Journal of neurology"}],"id":{"eki":["242065155"],"issn":["1432-1459"],"zdb":["1421299-7"]},"note":["Gesehen am 14.03.25","Ungezählte Beil.: Supplement"],"language":["eng","ger"],"type":{"bibl":"periodical","media":"Online-Ressource"}}],"person":[{"display":"Petereit, Hela-Felicitas","given":"Hela-Felicitas","role":"aut","family":"Petereit"},{"display":"Reske, Dirk","family":"Reske","role":"aut","given":"Dirk"},{"family":"Tumani","role":"aut","given":"Hayrettin","display":"Tumani, Hayrettin"},{"display":"Jarius, Sven","role":"aut","given":"Sven","family":"Jarius"},{"family":"Leweke","role":"aut","given":"F. Markus","display":"Leweke, F. Markus"},{"display":"Woitalla, Dirk","family":"Woitalla","role":"aut","given":"Dirk"},{"display":"Pfister, Hans-Walter","family":"Pfister","given":"Hans-Walter","role":"aut"},{"display":"Rubbert, Andrea","family":"Rubbert","given":"Andrea","role":"aut"}],"title":[{"title":"Soluble CSF interleukin 2 receptor as indicator of neurosarcoidosis","title_sort":"Soluble CSF interleukin 2 receptor as indicator of neurosarcoidosis"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"note":["Gesehen am 28.04.2023"],"recId":"1843789728","physDesc":[{"extent":"9 S."}]} | ||
| SRT | |a PETEREITHESOLUBLECSF1720 | ||