Immunotherapy with depigmented-polymerized mixed tree pollen extract: a clinical trial and responder analysis
Background: Rhinoconjunctivitis because of tree pollen sensitization is common in Northern Europe. Specific subcutaneous immunotherapy (SCIT) is the only disease-modifying treatment, but unmodified allergen extracts carry a risk of allergic side-effects. Our objective was to examine efficacy and saf...
Gespeichert in:
| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
29 October 2010
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| In: |
Allergy
Year: 2010, Jahrgang: 65, Heft: 12, Pages: 1614-1621 |
| ISSN: | 1398-9995 |
| DOI: | 10.1111/j.1398-9995.2010.02413.x |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1398-9995.2010.02413.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1398-9995.2010.02413.x 
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| Verfasserangaben: | O. Pfaar, D.S. Robinson, A. Sager & R. Emuzyte |
MARC
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| 245 | 1 | 0 | |a Immunotherapy with depigmented-polymerized mixed tree pollen extract |b a clinical trial and responder analysis |c O. Pfaar, D.S. Robinson, A. Sager & R. Emuzyte |
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| 520 | |a Background: Rhinoconjunctivitis because of tree pollen sensitization is common in Northern Europe. Specific subcutaneous immunotherapy (SCIT) is the only disease-modifying treatment, but unmodified allergen extracts carry a risk of allergic side-effects. Our objective was to examine efficacy and safety of a depigmented-polymerized mixed tree pollen extract. Methods: A double-blind, placebo-controlled trial of 184 tree pollen allergic adults was performed. SCIT consisted of four increasing doses at 7-day intervals, then maintenance injections every 6 weeks for 18 months. Primary outcome was combined symptom and medication score during the 2008 season. Secondary outcomes included analysis at different levels of pollen exposure and a responder analysis. Adverse events were classified using the EAACI scale. Birch pollen-specific IgE and IgG4 were measured before and after treatment. Results: The combined symptom and medication score of actively treated patients was significantly lower than those on placebo (P < 0.04). Increased efficacy was seen at high pollen exposure (median score 2.1 for active [IQR 0.7-3.4] vs 4.2 [IQR 2.4-5.3] for placebo for days with 500 or more pollen grains per m3, a 50% reduction, P < 0.01). A modified responder analysis revealed 64% responders in the active and 32% in the placebo group (P < 0.01). There were 17 systemic reactions. All were mild (grade 1 or 2) and required no treatment. Serum birch-specific IgG4 increased in the SCIT group (P < 0.01). Conclusions: SCIT with depigmented- polymerized tree pollen extract was clinically effective and well tolerated. Responder analysis suggested that one-third of patients treated with immunotherapy may not respond. | ||
| 650 | 4 | |a allergic rhinitis | |
| 650 | 4 | |a allergoid | |
| 650 | 4 | |a depigmented- polymerized allergen extract | |
| 650 | 4 | |a specific subcutaneous immunotherapy (SCIT) | |
| 650 | 4 | |a tree pollen | |
| 700 | 1 | |a Robinson, D. S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sager, A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Emuzyte, R. |e VerfasserIn |4 aut | |
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