Epistasis of the DRD2/ANKK1 Taq Ia and the BDNF Val66Met polymorphism impacts Novelty Seeking and Harm Avoidance
Mounting evidence from animal studies show that the mesolimbic dopaminergic pathways are modulated by the brain-derived neurotrophic factor (BDNF). This study investigates in N=768 healthy Caucasian participants the influence of two prominent functional single-nucleotide polymorphisms (SNPs) on the...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
21 April 2010
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| In: |
Neuropsychopharmacology
Year: 2010, Jahrgang: 35, Heft: 9, Pages: 1860-1867 |
| ISSN: | 1740-634X |
| DOI: | 10.1038/npp.2010.55 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/npp.2010.55 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/npp201055 
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| Verfasserangaben: | Christian Montag, Sebastian Markett, Ulrike Basten, Christine Stelzel, Christian Fiebach, Turhan Canli and Martin Reuter |
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| 520 | |a Mounting evidence from animal studies show that the mesolimbic dopaminergic pathways are modulated by the brain-derived neurotrophic factor (BDNF). This study investigates in N=768 healthy Caucasian participants the influence of two prominent functional single-nucleotide polymorphisms (SNPs) on the BDNF gene (BDNF Val66Met SNP) and the ankyrin repeat and kinase domain containing 1 (ANKK1) gene (DRD2 Taq Ia/ANKK1 SNP) on the personality traits of Novelty Seeking and Harm Avoidance, which are mediated, in part, through dopaminergic mesolimbic circuitry. Carriers of the 66Met+/A1+ variant scored lowest on Novelty Seeking and highest on Harm Avoidance, compared to all other genotype groups. These participants are characterized by a relatively low D2 receptor density in the striatum and an impaired activity-dependent secretion of BDNF. This is one of the first genetic association studies to show a modulatory role for BDNF genetic variation on genetically mediated differences in the mesolimbic dopaminergic system in the context of human personality. | ||
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