Insulin-resistant brain state (IRBS) changes membrane composition of fatty acids in temporal and entorhinal brain cortices of rats: relevance to sporadic Alzheimer’s disease?
An insulin-resistant brain state (IRBS) was induced by intracerebroventricular application of the diabetogenic substance streptozotocin (STZ) to investigate changes in cerebral fatty acids. Six weeks after the first STZ injection, increases were found in the concentrations of palmitic and stearic ac...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
07 December 2010
|
| In: |
Journal of neural transmission
Year: 2010, Jahrgang: 117, Heft: 12, Pages: 1419-1422 |
| ISSN: | 1435-1463 |
| DOI: | 10.1007/s00702-010-0523-3 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00702-010-0523-3
|
| Verfasserangaben: | Konstanze Plaschke, Dorothea Müller, Siegfried Hoyer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1844590046 | ||
| 003 | DE-627 | ||
| 005 | 20230710140539.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230504s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00702-010-0523-3 |2 doi | |
| 035 | |a (DE-627)1844590046 | ||
| 035 | |a (DE-599)KXP1844590046 | ||
| 035 | |a (OCoLC)1389805983 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Plaschke, Konstanze |e VerfasserIn |0 (DE-588)1058094637 |0 (DE-627)79637919X |0 (DE-576)171750365 |4 aut | |
| 245 | 1 | 0 | |a Insulin-resistant brain state (IRBS) changes membrane composition of fatty acids in temporal and entorhinal brain cortices of rats |b relevance to sporadic Alzheimer’s disease? |c Konstanze Plaschke, Dorothea Müller, Siegfried Hoyer |
| 264 | 1 | |c 07 December 2010 | |
| 300 | |a 4 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.05.2023 | ||
| 520 | |a An insulin-resistant brain state (IRBS) was induced by intracerebroventricular application of the diabetogenic substance streptozotocin (STZ) to investigate changes in cerebral fatty acids. Six weeks after the first STZ injection, increases were found in the concentrations of palmitic and stearic acid in temporal cortex; and of palmitic acid in entorhinal cortex indicative of membrane phospholipid breakdown, and damage of the membrane structure. The relevance of these changes is discussed in relation to sporadic Alzheimer’s disease. | ||
| 650 | 4 | |a Fatty acid | |
| 650 | 4 | |a Insulin | |
| 650 | 4 | |a IRBS | |
| 650 | 4 | |a Sporadic Alzheimer’s disease | |
| 700 | 1 | |a Müller, Dorothea |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hoyer, Siegfried |d 1933-2014 |e VerfasserIn |0 (DE-588)133236773 |0 (DE-627)539307343 |0 (DE-576)299715469 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neural transmission |d Wien [u.a.] : Springer, 1950 |g 117(2010), 12 vom: Dez., Seite 1419-1422 |h Online-Ressource |w (DE-627)300185901 |w (DE-600)1481655-6 |w (DE-576)09450542X |x 1435-1463 |7 nnas |a Insulin-resistant brain state (IRBS) changes membrane composition of fatty acids in temporal and entorhinal brain cortices of rats relevance to sporadic Alzheimer’s disease? |
| 773 | 1 | 8 | |g volume:117 |g year:2010 |g number:12 |g month:12 |g pages:1419-1422 |g extent:4 |a Insulin-resistant brain state (IRBS) changes membrane composition of fatty acids in temporal and entorhinal brain cortices of rats relevance to sporadic Alzheimer’s disease? |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00702-010-0523-3 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230504 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 133236773 |a Hoyer, Siegfried |m 133236773:Hoyer, Siegfried |d 910000 |d 912000 |e 910000PH133236773 |e 912000PH133236773 |k 0/910000/ |k 1/910000/912000/ |p 3 |y j | ||
| 998 | |g 1058094637 |a Plaschke, Konstanze |m 1058094637:Plaschke, Konstanze |d 910000 |d 910300 |d 50000 |e 910000PP1058094637 |e 910300PP1058094637 |e 50000PP1058094637 |k 0/910000/ |k 1/910000/910300/ |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1844590046 |e 4317812533 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2010","dateIssuedDisp":"07 December 2010"}],"note":["Gesehen am 04.05.2023"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title":"Insulin-resistant brain state (IRBS) changes membrane composition of fatty acids in temporal and entorhinal brain cortices of rats","subtitle":"relevance to sporadic Alzheimer’s disease?","title_sort":"Insulin-resistant brain state (IRBS) changes membrane composition of fatty acids in temporal and entorhinal brain cortices of rats"}],"language":["eng"],"person":[{"given":"Konstanze","role":"aut","display":"Plaschke, Konstanze","family":"Plaschke"},{"family":"Müller","display":"Müller, Dorothea","role":"aut","given":"Dorothea"},{"display":"Hoyer, Siegfried","family":"Hoyer","role":"aut","given":"Siegfried"}],"relHost":[{"disp":"Insulin-resistant brain state (IRBS) changes membrane composition of fatty acids in temporal and entorhinal brain cortices of rats relevance to sporadic Alzheimer’s disease?Journal of neural transmission","corporate":[{"display":"European Society for Clinical Neuropharmacology","role":"isb"}],"part":{"issue":"12","volume":"117","extent":"4","text":"117(2010), 12 vom: Dez., Seite 1419-1422","pages":"1419-1422","year":"2010"},"origin":[{"publisherPlace":"Wien [u.a.]","dateIssuedDisp":"1950-","dateIssuedKey":"1950","publisher":"Springer"}],"note":["Gesehen am 18.10.05"],"title":[{"title":"Journal of neural transmission","title_sort":"Journal of neural transmission"}],"titleAlt":[{"title":"Acta neurovegetativa"},{"title":"Journal of neuro-visceral relations"},{"title":"Journal of neural transmission / General section"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"recId":"300185901","pubHistory":["1.1950 -"],"id":{"zdb":["1481655-6"],"issn":["1435-1463"],"eki":["300185901"]}}],"id":{"doi":["10.1007/s00702-010-0523-3"],"eki":["1844590046"]},"name":{"displayForm":["Konstanze Plaschke, Dorothea Müller, Siegfried Hoyer"]},"physDesc":[{"extent":"4 S."}],"recId":"1844590046"} | ||
| SRT | |a PLASCHKEKOINSULINRES0720 | ||