Buchumschlag

Safety and immunogenicity of the malaria vaccine candidate GMZ2 in malaria-exposed, adult individuals from Lambaréné, Gabon

Malaria is still one of the major public health threats in sub-Saharan Africa. An effective vaccine could be a sustainable control measure that can be integrated into existing health infrastructures. The malaria vaccine candidate GMZ2 is a recombinant fusion protein of conserved parts of Plasmodium...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Mordmüller, Benjamin Gottlieb (VerfasserIn) , Szywon, Katja (VerfasserIn) , Greutelaers, Benedikt (VerfasserIn) , Esen, Meral (VerfasserIn) , Mewono, Ludovic (VerfasserIn) , Treut, Carolin (VerfasserIn) , Mürbeth, Raymund E. (VerfasserIn) , Chilengi, Roma (VerfasserIn) , Noor, Ramadhani (VerfasserIn) , Kilama, Wen L. (VerfasserIn) , Imoukhuede, Egeruan B. (VerfasserIn) , Imbault, Nathalie (VerfasserIn) , Leroy, Odile (VerfasserIn) , Theisen, Michael (VerfasserIn) , Jepsen, Søren (VerfasserIn) , Milligan, Paul (VerfasserIn) , Fendel, Rolf (VerfasserIn) , Kremsner, Peter G. (VerfasserIn) , Issifou, Saadou (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 7 August 2010
In: Vaccine
Year: 2010, Jahrgang: 28, Heft: 41, Pages: 6698-6703
ISSN:1873-2518
DOI:10.1016/j.vaccine.2010.07.085
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.vaccine.2010.07.085
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0264410X10011072
Volltext
Verfasserangaben:Benjamin Mordmüller, Katja Szywon, Benedikt Greutelaers, Meral Esen, Ludovic Mewono, Carolin Treut, Raymund E. Mürbeth, Roma Chilengi, Ramadhani Noor, Wen L. Kilama, Egeruan Babatunde Imoukhuede, Nathalie Imbault, Odile Leroy, Michael Theisen, Søren Jepsen, Paul Milligan, Rolf Fendel, Peter G. Kremsner, Saadou Issifou

MARC

LEADER 00000caa a2200000 c 4500
001 1844593037
003 DE-627
005 20230710140517.0
007 cr uuu---uuuuu
008 230504s2010 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.vaccine.2010.07.085  |2 doi 
035 |a (DE-627)1844593037 
035 |a (DE-599)KXP1844593037 
035 |a (OCoLC)1389806039 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Mordmüller, Benjamin Gottlieb  |d 1970-  |e VerfasserIn  |0 (DE-588)115720227  |0 (DE-627)691540187  |0 (DE-576)177542624  |4 aut 
245 1 0 |a Safety and immunogenicity of the malaria vaccine candidate GMZ2 in malaria-exposed, adult individuals from Lambaréné, Gabon  |c Benjamin Mordmüller, Katja Szywon, Benedikt Greutelaers, Meral Esen, Ludovic Mewono, Carolin Treut, Raymund E. Mürbeth, Roma Chilengi, Ramadhani Noor, Wen L. Kilama, Egeruan Babatunde Imoukhuede, Nathalie Imbault, Odile Leroy, Michael Theisen, Søren Jepsen, Paul Milligan, Rolf Fendel, Peter G. Kremsner, Saadou Issifou 
264 1 |c 7 August 2010 
300 |a 6 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 04.05.2023 
520 |a Malaria is still one of the major public health threats in sub-Saharan Africa. An effective vaccine could be a sustainable control measure that can be integrated into existing health infrastructures. The malaria vaccine candidate GMZ2 is a recombinant fusion protein of conserved parts of Plasmodium falciparum Glutamate Rich Protein and Merozoite Surface Protein 3 adjuvanted with aluminium hydroxide. GMZ2 is immunogenic and well tolerated in malaria-naive adults from Germany. To assess safety and immunogenicity in malaria-exposed individuals, 40 adults from Lambaréné, Gabon were randomly assigned to receive either 100μg GMZ2 or a rabies control vaccine three times in monthly intervals. Both vaccines were well tolerated. One month after a full course of vaccination, GMZ2-vaccinated individuals had 1.4-fold (95% confidence interval: [1.1, 1.7]) higher baseline-corrected anti-GMZ2 antibody levels and more GMZ2-specific memory B-cells compared to the rabies group (p=0.039), despite a high prevalence of GMZ2-specific immune reactivity due to previous intense exposure to P. falciparum. 
650 4 |a Malaria immunity 
650 4 |a Malaria vaccine 
650 4 |a Phase I clinical trial 
700 1 |a Szywon, Katja  |e VerfasserIn  |4 aut 
700 1 |a Greutelaers, Benedikt  |e VerfasserIn  |4 aut 
700 1 |a Esen, Meral  |e VerfasserIn  |4 aut 
700 1 |a Mewono, Ludovic  |e VerfasserIn  |4 aut 
700 1 |a Treut, Carolin  |e VerfasserIn  |4 aut 
700 1 |a Mürbeth, Raymund E.  |e VerfasserIn  |4 aut 
700 1 |a Chilengi, Roma  |e VerfasserIn  |4 aut 
700 1 |a Noor, Ramadhani  |e VerfasserIn  |4 aut 
700 1 |a Kilama, Wen L.  |e VerfasserIn  |4 aut 
700 1 |a Imoukhuede, Egeruan B.  |e VerfasserIn  |0 (DE-588)1078783578  |0 (DE-627)839454783  |0 (DE-576)451814126  |4 aut 
700 1 |a Imbault, Nathalie  |e VerfasserIn  |4 aut 
700 1 |a Leroy, Odile  |e VerfasserIn  |0 (DE-588)1081792701  |0 (DE-627)846672553  |0 (DE-576)45479732X  |4 aut 
700 1 |a Theisen, Michael  |e VerfasserIn  |4 aut 
700 1 |a Jepsen, Søren  |e VerfasserIn  |4 aut 
700 1 |a Milligan, Paul  |e VerfasserIn  |4 aut 
700 1 |a Fendel, Rolf  |e VerfasserIn  |4 aut 
700 1 |a Kremsner, Peter G.  |e VerfasserIn  |4 aut 
700 1 |a Issifou, Saadou  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Vaccine  |d Amsterdam : Elsevier, 1983  |g 28(2010), 41, Seite 6698-6703  |h Online-Ressource  |w (DE-627)266886078  |w (DE-600)1468474-3  |w (DE-576)075961857  |x 1873-2518  |7 nnas  |a Safety and immunogenicity of the malaria vaccine candidate GMZ2 in malaria-exposed, adult individuals from Lambaréné, Gabon 
773 1 8 |g volume:28  |g year:2010  |g number:41  |g pages:6698-6703  |g extent:6  |a Safety and immunogenicity of the malaria vaccine candidate GMZ2 in malaria-exposed, adult individuals from Lambaréné, Gabon 
856 4 0 |u https://doi.org/10.1016/j.vaccine.2010.07.085  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S0264410X10011072  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20230504 
993 |a Article 
994 |a 2010 
998 |g 1081792701  |a Leroy, Odile  |m 1081792701:Leroy, Odile  |p 13 
998 |g 1078783578  |a Imoukhuede, Egeruan B.  |m 1078783578:Imoukhuede, Egeruan B.  |p 11 
999 |a KXP-PPN1844593037  |e 431781871X 
BIB |a Y 
SER |a journal 
JSO |a {"relHost":[{"title":[{"title_sort":"Vaccine","title":"Vaccine"}],"language":["eng"],"recId":"266886078","note":["Gesehen am 19.10.07","Ungezählte Beil.: Supplement"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Safety and immunogenicity of the malaria vaccine candidate GMZ2 in malaria-exposed, adult individuals from Lambaréné, GabonVaccine","part":{"year":"2010","issue":"41","pages":"6698-6703","volume":"28","text":"28(2010), 41, Seite 6698-6703","extent":"6"},"pubHistory":["1.1983 -"],"id":{"eki":["266886078"],"zdb":["1468474-3"],"issn":["1873-2518"]},"origin":[{"dateIssuedKey":"1983","publisher":"Elsevier","dateIssuedDisp":"1983-","publisherPlace":"Amsterdam"}],"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"6 S."}],"name":{"displayForm":["Benjamin Mordmüller, Katja Szywon, Benedikt Greutelaers, Meral Esen, Ludovic Mewono, Carolin Treut, Raymund E. Mürbeth, Roma Chilengi, Ramadhani Noor, Wen L. Kilama, Egeruan Babatunde Imoukhuede, Nathalie Imbault, Odile Leroy, Michael Theisen, Søren Jepsen, Paul Milligan, Rolf Fendel, Peter G. Kremsner, Saadou Issifou"]},"id":{"eki":["1844593037"],"doi":["10.1016/j.vaccine.2010.07.085"]},"origin":[{"dateIssuedDisp":"7 August 2010","dateIssuedKey":"2010"}],"language":["eng"],"recId":"1844593037","note":["Gesehen am 04.05.2023"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"family":"Mordmüller","given":"Benjamin Gottlieb","roleDisplay":"VerfasserIn","display":"Mordmüller, Benjamin Gottlieb","role":"aut"},{"family":"Szywon","given":"Katja","roleDisplay":"VerfasserIn","display":"Szywon, Katja","role":"aut"},{"display":"Greutelaers, Benedikt","roleDisplay":"VerfasserIn","role":"aut","family":"Greutelaers","given":"Benedikt"},{"family":"Esen","given":"Meral","roleDisplay":"VerfasserIn","display":"Esen, Meral","role":"aut"},{"given":"Ludovic","family":"Mewono","role":"aut","display":"Mewono, Ludovic","roleDisplay":"VerfasserIn"},{"given":"Carolin","family":"Treut","role":"aut","display":"Treut, Carolin","roleDisplay":"VerfasserIn"},{"display":"Mürbeth, Raymund E.","roleDisplay":"VerfasserIn","role":"aut","family":"Mürbeth","given":"Raymund E."},{"family":"Chilengi","given":"Roma","display":"Chilengi, Roma","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","display":"Noor, Ramadhani","roleDisplay":"VerfasserIn","given":"Ramadhani","family":"Noor"},{"roleDisplay":"VerfasserIn","display":"Kilama, Wen L.","role":"aut","family":"Kilama","given":"Wen L."},{"roleDisplay":"VerfasserIn","display":"Imoukhuede, Egeruan B.","role":"aut","family":"Imoukhuede","given":"Egeruan B."},{"role":"aut","roleDisplay":"VerfasserIn","display":"Imbault, Nathalie","given":"Nathalie","family":"Imbault"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Leroy, Odile","given":"Odile","family":"Leroy"},{"family":"Theisen","given":"Michael","display":"Theisen, Michael","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Jepsen, Søren","role":"aut","family":"Jepsen","given":"Søren"},{"display":"Milligan, Paul","roleDisplay":"VerfasserIn","role":"aut","family":"Milligan","given":"Paul"},{"given":"Rolf","family":"Fendel","role":"aut","display":"Fendel, Rolf","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Kremsner, Peter G.","roleDisplay":"VerfasserIn","given":"Peter G.","family":"Kremsner"},{"display":"Issifou, Saadou","roleDisplay":"VerfasserIn","role":"aut","family":"Issifou","given":"Saadou"}],"title":[{"title":"Safety and immunogenicity of the malaria vaccine candidate GMZ2 in malaria-exposed, adult individuals from Lambaréné, Gabon","title_sort":"Safety and immunogenicity of the malaria vaccine candidate GMZ2 in malaria-exposed, adult individuals from Lambaréné, Gabon"}]} 
SRT |a MORDMUELLESAFETYANDI7201 

Ähnliche Einträge