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Spreading depolarizations cycle around and enlarge focal ischaemic brain lesions

How does infarction in victims of stroke and other types of acute brain injury expand to its definitive size in subsequent days? Spontaneous depolarizations that repeatedly spread across the cerebral cortex, sometimes at remarkably regular intervals, occur in patients with all types of injury. Here,...

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Hauptverfasser: Nakamura, Hajime (VerfasserIn) , Strong, Anthony J. (VerfasserIn) , Dohmen, Christian (VerfasserIn) , Sakowitz, Oliver (VerfasserIn) , Vollmar, Stefan (VerfasserIn) , Sué, Michael (VerfasserIn) , Kracht, Lutz (VerfasserIn) , Hashemi, Parastoo (VerfasserIn) , Bhatia, Robin (VerfasserIn) , Yoshimine, Toshiki (VerfasserIn) , Dreier, Jens P. (VerfasserIn) , Dunn, Andrew K. (VerfasserIn) , Graf, Rudolf (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: May 26, 2010
In: Brain
Year: 2010, Jahrgang: 133, Heft: 7, Pages: 1994-2006
ISSN:1460-2156
DOI:10.1093/brain/awq117
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/brain/awq117
Volltext
Verfasserangaben:Hajime Nakamura, Anthony J. Strong, Christian Dohmen, Oliver W. Sakowitz, Stefan Vollmar, Michael Sué, Lutz Kracht, Parastoo Hashemi, Robin Bhatia, Toshiki Yoshimine, Jens P. Dreier, Andrew K. Dunn and Rudolf Graf
Beschreibung
Zusammenfassung:How does infarction in victims of stroke and other types of acute brain injury expand to its definitive size in subsequent days? Spontaneous depolarizations that repeatedly spread across the cerebral cortex, sometimes at remarkably regular intervals, occur in patients with all types of injury. Here, we show experimentally with in vivo real-time imaging that similar, spontaneous depolarizations cycle repeatedly around ischaemic lesions in the cerebral cortex, and enlarge the lesion in step with each cycle. This behaviour results in regular periodicity of depolarization when monitored at a single point in the lesion periphery. We present evidence from clinical monitoring to suggest that depolarizations may cycle in the ischaemic human brain, perhaps explaining progressive growth of infarction. Despite their apparent detrimental role in infarct growth, we argue that cycling of depolarizations around lesions might also initiate upregulation of the neurobiological responses involved in repair and remodelling.
Beschreibung:Gesehen am 05.05.2023
Beschreibung:Online Resource
ISSN:1460-2156
DOI:10.1093/brain/awq117

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