Efficacy and outcome of autologous transplantation in rare myelomas
Background As rare myelomas, i.e. the IgD, IgE, IgM and non-secretory forms, constitute only a small proportion of any study, relatively little is known about their prognosis in the era of peripheral stem cell transplantation.Design and Methods We used the European Group for Blood and Marrow Transpl...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2010
|
| In: |
Haematologica, the hematology journal
Year: 2010, Jahrgang: 95, Heft: 12, Pages: 2126-2133 |
| ISSN: | 1592-8721 |
| DOI: | 10.3324/haematol.2010.022848 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3324/haematol.2010.022848 Verlag, lizenzpflichtig, Volltext: https://haematologica.org/article/view/5822 
|
| Verfasserangaben: | Curly Morris, Mary Drake, Jane Apperley, Simona Iacobelli, Anja van Biezen, Bo Bjorkstrand, Hartmut Goldschmidt, Jean-Luc Harousseau, Gareth Morgan, Theo de Witte, Dietger Niederwieser, and Gosta Gahrton for the Myeloma Subcommittee of the Chronic Leukaemia Working Party of the EBMT |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1844658473 | ||
| 003 | DE-627 | ||
| 005 | 20230710140239.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230505s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3324/haematol.2010.022848 |2 doi | |
| 035 | |a (DE-627)1844658473 | ||
| 035 | |a (DE-599)KXP1844658473 | ||
| 035 | |a (OCoLC)1389805927 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Morris, Curly |e VerfasserIn |0 (DE-588)1288169809 |0 (DE-627)1844659097 |4 aut | |
| 245 | 1 | 0 | |a Efficacy and outcome of autologous transplantation in rare myelomas |c Curly Morris, Mary Drake, Jane Apperley, Simona Iacobelli, Anja van Biezen, Bo Bjorkstrand, Hartmut Goldschmidt, Jean-Luc Harousseau, Gareth Morgan, Theo de Witte, Dietger Niederwieser, and Gosta Gahrton for the Myeloma Subcommittee of the Chronic Leukaemia Working Party of the EBMT |
| 264 | 1 | |c 2010 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.05.2023 | ||
| 520 | |a Background As rare myelomas, i.e. the IgD, IgE, IgM and non-secretory forms, constitute only a small proportion of any study, relatively little is known about their prognosis in the era of peripheral stem cell transplantation.Design and Methods We used the European Group for Blood and Marrow Transplantation Myeloma Database to compare the outcome following autologous transplantation of over 20,000 patients with common myelomas (IgG, IgA and light chain myeloma) with the outcome of patients with rare myelomas: 379 IgD, 13 IgE, 72 IgM and 976 non-secretory cases.Results The study confirms the multiple adverse prognostic factors seen in IgD myeloma. Somewhat surprisingly, patients with IgD and non-secretory myeloma both had higher complete remission rates before and after transplantation than patients with common myelomas. However, while the overall survival of patients with non-secretory myeloma was similar to that of the patients with common myelomas, the survival of patients with IgD myeloma was significantly worse (although better than survival rates reported for non-transplanted patients); this was due to higher transplant-related mortality and relapse/progression rates. The post-transplantation survival of patients with IgE or IgM myeloma appears to be very poor.Conclusions This study provides data on the biological features of rare myelomas. The overall survival of patients with IgD, IgE or IgM myeloma is poor following autologous transplantation but substantially better than that reported for patients who were not transplanted. | ||
| 700 | 1 | |a Drake, Mary |e VerfasserIn |4 aut | |
| 700 | 1 | |a Apperley, Jane |e VerfasserIn |4 aut | |
| 700 | 1 | |a Iacobelli, Simona |e VerfasserIn |4 aut | |
| 700 | 1 | |a Biezen, Anja van |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bjorkstrand, Bo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Goldschmidt, Hartmut |d 1956- |e VerfasserIn |0 (DE-588)102258023X |0 (DE-627)717003809 |0 (DE-576)365637386 |4 aut | |
| 700 | 1 | |a Harousseau, Jean-Luc |e VerfasserIn |4 aut | |
| 700 | 1 | |a Morgan, Gareth |e VerfasserIn |4 aut | |
| 700 | 1 | |a Witte, Theo de |e VerfasserIn |4 aut | |
| 700 | 1 | |a Niederwieser, Dietger |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gahrton, Gosta |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Haematologica, the hematology journal |d Pavia : Ferrata Storti Foundation, 2005 |g 95(2010), 12, Seite 2126-2133 |h Online-Ressource |w (DE-627)48524375X |w (DE-600)2186022-1 |w (DE-576)414771095 |x 1592-8721 |7 nnas |a Efficacy and outcome of autologous transplantation in rare myelomas |
| 773 | 1 | 8 | |g volume:95 |g year:2010 |g number:12 |g pages:2126-2133 |g extent:8 |a Efficacy and outcome of autologous transplantation in rare myelomas |
| 856 | 4 | 0 | |u https://doi.org/10.3324/haematol.2010.022848 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://haematologica.org/article/view/5822 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230505 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 102258023X |a Goldschmidt, Hartmut |m 102258023X:Goldschmidt, Hartmut |d 910000 |d 910100 |d 50000 |e 910000PG102258023X |e 910100PG102258023X |e 50000PG102258023X |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 7 | ||
| 999 | |a KXP-PPN1844658473 |e 431819048X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"given":"Curly","role":"aut","family":"Morris","display":"Morris, Curly"},{"role":"aut","given":"Mary","display":"Drake, Mary","family":"Drake"},{"display":"Apperley, Jane","family":"Apperley","given":"Jane","role":"aut"},{"role":"aut","given":"Simona","display":"Iacobelli, Simona","family":"Iacobelli"},{"given":"Anja van","role":"aut","family":"Biezen","display":"Biezen, Anja van"},{"family":"Bjorkstrand","display":"Bjorkstrand, Bo","role":"aut","given":"Bo"},{"display":"Goldschmidt, Hartmut","family":"Goldschmidt","role":"aut","given":"Hartmut"},{"family":"Harousseau","display":"Harousseau, Jean-Luc","role":"aut","given":"Jean-Luc"},{"given":"Gareth","role":"aut","family":"Morgan","display":"Morgan, Gareth"},{"given":"Theo de","role":"aut","family":"Witte","display":"Witte, Theo de"},{"display":"Niederwieser, Dietger","family":"Niederwieser","role":"aut","given":"Dietger"},{"role":"aut","given":"Gosta","family":"Gahrton","display":"Gahrton, Gosta"}],"language":["eng"],"origin":[{"dateIssuedDisp":"2010","dateIssuedKey":"2010"}],"note":["Gesehen am 04.05.2023"],"title":[{"title":"Efficacy and outcome of autologous transplantation in rare myelomas","title_sort":"Efficacy and outcome of autologous transplantation in rare myelomas"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"name":{"displayForm":["Curly Morris, Mary Drake, Jane Apperley, Simona Iacobelli, Anja van Biezen, Bo Bjorkstrand, Hartmut Goldschmidt, Jean-Luc Harousseau, Gareth Morgan, Theo de Witte, Dietger Niederwieser, and Gosta Gahrton for the Myeloma Subcommittee of the Chronic Leukaemia Working Party of the EBMT"]},"physDesc":[{"extent":"8 S."}],"relHost":[{"part":{"year":"2010","pages":"2126-2133","text":"95(2010), 12, Seite 2126-2133","issue":"12","volume":"95","extent":"8"},"language":["eng"],"id":{"eki":["48524375X"],"zdb":["2186022-1"],"issn":["1592-8721"]},"recId":"48524375X","physDesc":[{"extent":"Online-Ressource"}],"disp":"Efficacy and outcome of autologous transplantation in rare myelomasHaematologica, the hematology journal","type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"2005-2013","dateIssuedKey":"2005","publisher":"Ferrata Storti Foundation","publisherPlace":"Pavia"}],"note":["Gesehen am 27.09.2018"],"pubHistory":["90.2005 - 98.2013"],"title":[{"title_sort":"Haematologica, the hematology journal","subtitle":"official organ of the European Hematology Association","title":"Haematologica, the hematology journal"}]}],"recId":"1844658473","id":{"doi":["10.3324/haematol.2010.022848"],"eki":["1844658473"]}} | ||
| SRT | |a MORRISCURLEFFICACYAN2010 | ||