Salinomycin in cancer: a new mission for an old agent
Salinomycin is a monocarboxylic polyether ionophore isolated from Streptomyces albus that has been used for more than 30 years as an agricultural antibiotic to prevent coccidiosis in poultry and to improve nutrient absorption and feed efficiency in ruminants and swine. As a inonophore with strict se...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 1, 2010
|
| In: |
Molecular medicine reports
Year: 2010, Jahrgang: 3, Heft: 4, Pages: 555-559 |
| ISSN: | 1791-3004 |
| DOI: | 10.3892/mmr_00000296 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3892/mmr_00000296 Verlag, lizenzpflichtig, Volltext: https://www.spandidos-publications.com/10.3892/mmr_00000296 
|
| Verfasserangaben: | Cord Naujokat, Dominik Fuchs and Gerhard Opelz |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1844670643 | ||
| 003 | DE-627 | ||
| 005 | 20230710140013.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230505s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3892/mmr_00000296 |2 doi | |
| 035 | |a (DE-627)1844670643 | ||
| 035 | |a (DE-599)KXP1844670643 | ||
| 035 | |a (OCoLC)1389805944 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Naujokat, Cord |d 1964- |e VerfasserIn |0 (DE-588)123190592 |0 (DE-627)082401616 |0 (DE-576)184229537 |4 aut | |
| 245 | 1 | 0 | |a Salinomycin in cancer |b a new mission for an old agent |c Cord Naujokat, Dominik Fuchs and Gerhard Opelz |
| 264 | 1 | |c July 1, 2010 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 05.05.2023 | ||
| 520 | |a Salinomycin is a monocarboxylic polyether ionophore isolated from Streptomyces albus that has been used for more than 30 years as an agricultural antibiotic to prevent coccidiosis in poultry and to improve nutrient absorption and feed efficiency in ruminants and swine. As a inonophore with strict selectivety for alkali ions and a strong preference for potassium, salinomycin interferes with transmembrane potassium potential and promotes the efflux of K+ ions from mitochondria and cytoplasm. Salinomycin has recently been shown to kill human cancer stem cells and to inhibit breast cancer growth and metastasis in mice. Salinomycin is also able to induce massive apoptosis in human cancer cells of different origins that display multiple mechanisms of drug and apoptosis resistance. Salinomycin activates an unconventional pathway of apoptosis in human cancer cells that may contribute to the breakdown of apoptosis resistance. The ability of salinomycin to effectively kill both cancer stem cells and apoptosis-resistant cancer cells may define the compound as a novel and effective anticancer agent. | ||
| 700 | 1 | |a Fuchs, Dominik |d 1978- |e VerfasserIn |0 (DE-588)13900694X |0 (DE-627)703178792 |0 (DE-576)309794803 |4 aut | |
| 700 | 1 | |a Opelz, Gerhard |d 1944- |e VerfasserIn |0 (DE-588)1026480345 |0 (DE-627)726772453 |0 (DE-576)371826527 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Molecular medicine reports |d Athens : Spandidos Publ., 2008 |g 3(2010), 4, Seite 555-559 |h Online-Ressource |w (DE-627)587890908 |w (DE-600)2469505-1 |w (DE-576)372068057 |x 1791-3004 |7 nnas |a Salinomycin in cancer a new mission for an old agent |
| 773 | 1 | 8 | |g volume:3 |g year:2010 |g number:4 |g pages:555-559 |g extent:5 |a Salinomycin in cancer a new mission for an old agent |
| 856 | 4 | 0 | |u https://doi.org/10.3892/mmr_00000296 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.spandidos-publications.com/10.3892/mmr_00000296 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230505 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 1026480345 |a Opelz, Gerhard |m 1026480345:Opelz, Gerhard |d 910000 |d 911600 |e 910000PO1026480345 |e 911600PO1026480345 |k 0/910000/ |k 1/910000/911600/ |p 3 |y j | ||
| 998 | |g 123190592 |a Naujokat, Cord |m 123190592:Naujokat, Cord |d 50000 |e 50000PN123190592 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1844670643 |e 4318224678 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1844670643","language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 05.05.2023"],"person":[{"family":"Naujokat","given":"Cord","roleDisplay":"VerfasserIn","display":"Naujokat, Cord","role":"aut"},{"role":"aut","display":"Fuchs, Dominik","roleDisplay":"VerfasserIn","given":"Dominik","family":"Fuchs"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Opelz, Gerhard","given":"Gerhard","family":"Opelz"}],"title":[{"title_sort":"Salinomycin in cancer","title":"Salinomycin in cancer","subtitle":"a new mission for an old agent"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2469505-1"],"eki":["587890908"],"issn":["1791-3004"]},"origin":[{"dateIssuedDisp":"2008-","publisher":"Spandidos Publ.","dateIssuedKey":"2008","publisherPlace":"Athens"}],"part":{"pages":"555-559","issue":"4","year":"2010","extent":"5","volume":"3","text":"3(2010), 4, Seite 555-559"},"pubHistory":["1.2008 -"],"language":["eng"],"recId":"587890908","disp":"Salinomycin in cancer a new mission for an old agentMolecular medicine reports","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 03.04.2025"],"title":[{"title":"Molecular medicine reports","title_sort":"Molecular medicine reports"}]}],"physDesc":[{"extent":"5 S."}],"name":{"displayForm":["Cord Naujokat, Dominik Fuchs and Gerhard Opelz"]},"id":{"doi":["10.3892/mmr_00000296"],"eki":["1844670643"]},"origin":[{"dateIssuedKey":"2010","dateIssuedDisp":"July 1, 2010"}]} | ||
| SRT | |a NAUJOKATCOSALINOMYCI1201 | ||