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Increased level of arginase activity correlates with disease severity in HIV-seropositive patients

Infection with human immunodeficiency virus (HIV) results in a chronic infection that progressively impairs the immune system. Although depletion of CD4(+) T cells is frequently used to explain immunosuppression, chronicity of infection and progressive loss of CD4(+) T cells are not sufficient to fu...

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Main Authors: Cloke, Thomas (Author) , Garvey, L. (Author) , Choi, B.-S. (Author) , Abebe, T. (Author) , Hailu, A. (Author) , Hancock, M. (Author) , Kadolsky, U. (Author) , Bangham, C. R. M. (Author) , Munder, Markus (Author) , Müller, I. (Author) , Taylor, G. P. (Author) , Kropf, P. (Author)
Format: Article (Journal)
Language:English
Published: 01 August 2010
In: The journal of infectious diseases
Year: 2010, Volume: 202, Issue: 3, Pages: 374-385
ISSN:1537-6613
DOI:10.1086/653736
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1086/653736
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Author Notes:T.E. Cloke, L. Garvey, B.-S. Choi, T. Abebe, A. Hailu, M. Hancock, U. Kadolsky, C.R.M. Bangham, M. Munder, I. Müller, G.P. Taylor, and P. Kropf

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520 |a Infection with human immunodeficiency virus (HIV) results in a chronic infection that progressively impairs the immune system. Although depletion of CD4(+) T cells is frequently used to explain immunosuppression, chronicity of infection and progressive loss of CD4(+) T cells are not sufficient to fully account for immune dysregulation. Arginase-induced l-arginine deprivation is emerging as a key mechanism for the down-regulation of immune responses. Here, we hypothesized that the level of arginase activity increases with disease severity in HIV-seropositive patients. We determined the levels of arginase activity in peripheral blood mononuclear cells from HIV-seropositive patients and uninfected control participants. Our results show that peripheral blood mononuclear cells from HIV-seropositive patients with low CD4(+) T cell counts expressed statistically significantly higher levels of arginase activity, compared with patients with high CD4(+) T cell counts or uninfected control participants. Furthermore, we found a statistically significant correlation between high level of arginase activity and high viral load in HIV-seropositive patients. 
650 4 |a Adult 
650 4 |a Arginase 
650 4 |a CD4 Lymphocyte Count 
650 4 |a Cells, Cultured 
650 4 |a Female 
650 4 |a HIV 
650 4 |a HIV Infections 
650 4 |a Humans 
650 4 |a Leukocytes, Mononuclear 
650 4 |a Male 
650 4 |a Middle Aged 
650 4 |a Severity of Illness Index 
650 4 |a Viral Load 
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700 1 |a Müller, I.  |e VerfasserIn  |4 aut 
700 1 |a Taylor, G. P.  |e VerfasserIn  |4 aut 
700 1 |a Kropf, P.  |e VerfasserIn  |4 aut 
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