High ICP as trigger of proinflammatory IL-6 cytokine activation in aneurysmal subarachnoid hemorrhage
OBJECTIVE: There is a rising debate about the role of inflammation in the pathogenesis of complications after aneurysmal subarachnoid hemorrhage (SAH) such as intracranial hypertension (intracranial pressure, ICP >20 mmHg). This study aimed to analyse the origin of interleukin-6 (IL-6) in respect...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2010 Sep
|
| In: |
Neurological research
Year: 2010, Volume: 32, Issue: 7, Pages: 728-735 |
| ISSN: | 1743-1328 |
| Online Access: |
|
| Author Notes: | Daniela Graetz, Alexandra Nagel, Florian Schlenk, Oliver Sakowitz, Peter Vajkoczy, Asita Sarrafzadeh |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1844715329 | ||
| 003 | DE-627 | ||
| 005 | 20230710135713.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230505s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1179/016164109X12464612122650 |2 doi | |
| 035 | |a (DE-627)1844715329 | ||
| 035 | |a (DE-599)KXP1844715329 | ||
| 035 | |a (OCoLC)1389805923 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Graetz, Daniela |e VerfasserIn |4 aut | |
| 245 | 1 | 0 | |a High ICP as trigger of proinflammatory IL-6 cytokine activation in aneurysmal subarachnoid hemorrhage |c Daniela Graetz, Alexandra Nagel, Florian Schlenk, Oliver Sakowitz, Peter Vajkoczy, Asita Sarrafzadeh |
| 264 | 1 | |c 2010 Sep | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 05.05.2023 | ||
| 520 | |a OBJECTIVE: There is a rising debate about the role of inflammation in the pathogenesis of complications after aneurysmal subarachnoid hemorrhage (SAH) such as intracranial hypertension (intracranial pressure, ICP >20 mmHg). This study aimed to analyse the origin of interleukin-6 (IL-6) in respect to ICP and cerebral metabolism in SAH patients. - METHODS: Prospectively, IL-6 was measured in three compartments, the extracellular fluid (ECF) monitored by cerebral microdialysis (MD), cerebrospinal fluid (CSF) and plasma for 10 days after SAH (days 0-4, three times daily; days 5-10, two times daily). Patients were classified having intracranial hypertension (n=7) or normal ICP (n=17) during 10 days after bleeding. Glasgow outcome scale (GOS) was assessed after 3 and 6 months. - RESULTS: Patient groups were comparable for age, WFNS and Fisher grade. Intracranial hypertension was associated with an inflammatory response, indicating activation of the inflammatory cascade in the brain (ECF) and systemic circulation with high IL-6 and C-reactive protein (CRP) plasma levels after SAH, the latter associated with unfavourable outcome. The data suggest the ECF but not the CSF as main origin of IL-6 in the systemic circulation in the presence of intracranial hypertension in SAH. - DISCUSSION: Intracranial hypertension is associated with a strong activation of the inflammatory cascade in the brain and systemic circulation, and might be underestimated as proinflammmatory trigger in the pathogenesis of complications after SAH. Future therapies targeting anti-inflammatory response in plasma may help to reduce the inflammatory cascade responsible for development of intracranial hypertension. | ||
| 650 | 4 | |a Adult | |
| 650 | 4 | |a C-Reactive Protein | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Glasgow Outcome Scale | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Immunoassay | |
| 650 | 4 | |a Interleukin-6 | |
| 650 | 4 | |a Intracranial Hypertension | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Microdialysis | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Statistics, Nonparametric | |
| 650 | 4 | |a Subarachnoid Hemorrhage | |
| 700 | 1 | |a Nagel, Alexandra |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schlenk, Florian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sakowitz, Oliver |d 1971- |e VerfasserIn |0 (DE-588)123767075 |0 (DE-627)706419928 |0 (DE-576)293869189 |4 aut | |
| 700 | 1 | |a Vajkoczy, Peter |d 1968- |e VerfasserIn |0 (DE-588)115313885 |0 (DE-627)537492593 |0 (DE-576)289826012 |4 aut | |
| 700 | 1 | |a Sarrafzadeh-Khorassani, Asita |d 1967- |e VerfasserIn |0 (DE-588)129405833 |0 (DE-627)396068707 |0 (DE-576)297644009 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neurological research |d Abingdon, Oxon : Taylor & Francis, 1979 |g 32(2010), 7, Seite 728-735 |h Online-Ressource |w (DE-627)345201078 |w (DE-600)2074874-7 |w (DE-576)099026007 |x 1743-1328 |7 nnas |a High ICP as trigger of proinflammatory IL-6 cytokine activation in aneurysmal subarachnoid hemorrhage |
| 773 | 1 | 8 | |g volume:32 |g year:2010 |g number:7 |g pages:728-735 |g extent:8 |a High ICP as trigger of proinflammatory IL-6 cytokine activation in aneurysmal subarachnoid hemorrhage |
| 951 | |a AR | ||
| 992 | |a 20230505 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 123767075 |a Sakowitz, Oliver |m 123767075:Sakowitz, Oliver |d 910000 |d 911100 |e 910000PS123767075 |e 911100PS123767075 |k 0/910000/ |k 1/910000/911100/ |p 4 | ||
| 999 | |a KXP-PPN1844715329 |e 4318292010 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 05.05.2023"],"name":{"displayForm":["Daniela Graetz, Alexandra Nagel, Florian Schlenk, Oliver Sakowitz, Peter Vajkoczy, Asita Sarrafzadeh"]},"recId":"1844715329","origin":[{"dateIssuedDisp":"2010 Sep","dateIssuedKey":"2010"}],"person":[{"role":"aut","display":"Graetz, Daniela","given":"Daniela","family":"Graetz"},{"role":"aut","display":"Nagel, Alexandra","given":"Alexandra","family":"Nagel"},{"role":"aut","display":"Schlenk, Florian","given":"Florian","family":"Schlenk"},{"given":"Oliver","family":"Sakowitz","role":"aut","display":"Sakowitz, Oliver"},{"role":"aut","display":"Vajkoczy, Peter","given":"Peter","family":"Vajkoczy"},{"display":"Sarrafzadeh-Khorassani, Asita","role":"aut","family":"Sarrafzadeh-Khorassani","given":"Asita"}],"language":["eng"],"title":[{"title_sort":"High ICP as trigger of proinflammatory IL-6 cytokine activation in aneurysmal subarachnoid hemorrhage","title":"High ICP as trigger of proinflammatory IL-6 cytokine activation in aneurysmal subarachnoid hemorrhage"}],"relHost":[{"recId":"345201078","origin":[{"dateIssuedKey":"1979","publisherPlace":"Abingdon, Oxon ; London ; Leeds","dateIssuedDisp":"1979-","publisher":"Taylor & Francis ; Forefront Publ. ; Maney"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"id":{"eki":["345201078"],"issn":["1743-1328"],"zdb":["2074874-7"]},"part":{"year":"2010","extent":"8","volume":"32","text":"32(2010), 7, Seite 728-735","pages":"728-735","issue":"7"},"pubHistory":["1.1979 -"],"disp":"High ICP as trigger of proinflammatory IL-6 cytokine activation in aneurysmal subarachnoid hemorrhageNeurological research","note":["Gesehen am 14.02.2017"],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Neurological research","subtitle":"a journal of progress in neurosurgery and neurosciences","title":"Neurological research"}]}],"physDesc":[{"extent":"8 S."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1844715329"],"doi":["10.1179/016164109X12464612122650"]}} | ||
| SRT | |a GRAETZDANIHIGHICPAST2010 | ||