Influence of HPV16 E2 and its localisation on the expression of matrix metalloproteinase-9
Infection with the high-risk HPV types 16 and 18 is the major cause of cervical cancer and plays a role in the development of certain head and neck and skin cancers. We have previously demonstrated that the Early Protein 2 of the Cottontail Rabbit papillomavirus (CRPV), required for skin carcinogene...
Gespeichert in:
| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
August 1, 2010
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| In: |
International journal of oncology
Year: 2010, Jahrgang: 37, Heft: 2, Pages: 337-345 |
| ISSN: | 1791-2423 |
| DOI: | 10.3892/ijo_00000682 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3892/ijo_00000682 Verlag, lizenzpflichtig, Volltext: https://www.spandidos-publications.com/10.3892/ijo_00000682 
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| Verfasserangaben: | Sabrina Mühlen, Andreas Behren, Thomas Iftner and Christian Simon |
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| 520 | |a Infection with the high-risk HPV types 16 and 18 is the major cause of cervical cancer and plays a role in the development of certain head and neck and skin cancers. We have previously demonstrated that the Early Protein 2 of the Cottontail Rabbit papillomavirus (CRPV), required for skin carcinogenesis in a rabbit model, is able to induce the expression of a matrix metalloproteinase (MMP-9); a protease known to play a key role in invasion and metastasis. However, as of now we do not understand the underlying mechanism of activation nor relevance for the human system. Here, we report that high-risk human papillomavirus HPV16 E2 similar to our previously reported results on CRPV E2 activates the human MMP-9 promoter predominantly via the MEK1-ERK1/2-AP-1-signaling pathway. In addition this activation is associated with a nuclear sub-localisation of HPV16-E2 suggesting a nuclear protein-protein or protein-DNA interaction of E2 as the underlying mechanism of activation. | ||
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