CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation$nletters
Recent studies have shown that neutrophil extracellular traps (NETs) can capture and kill bacteria but may also contribute to chronic inflammation. The mechanisms that trigger NET formation are not yet fully elucidated. Marcos et al. now report that stimulation of the chemokine receptor CXCR, induce...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
05 September 2010
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| In: |
Nature medicine
Year: 2010, Jahrgang: 16, Heft: 9, Pages: 1018-1023 |
| ISSN: | 1546-170X |
| DOI: | 10.1038/nm.2209 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nm.2209 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nm.2209 
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| Verfasserangaben: | Veronica Marcos, Zhe Zhou, Ali Önder Yildirim, Alexander Bohla, Andreas Hector, Ljubomir Vitkov, Eva-Maria Wiedenbauer, Wolf Dietrich Krautgartner, Walter Stoiber, Bernd H Belohradsky, Nikolaus Rieber, Michael Kormann, Barbara Koller, Adelbert Roscher, Dirk Roos, Matthias Griese, Oliver Eickelberg, Gerd Döring, Marcus A Mall & Dominik Hartl |
MARC
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| 245 | 1 | 0 | |a CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation$nletters |c Veronica Marcos, Zhe Zhou, Ali Önder Yildirim, Alexander Bohla, Andreas Hector, Ljubomir Vitkov, Eva-Maria Wiedenbauer, Wolf Dietrich Krautgartner, Walter Stoiber, Bernd H Belohradsky, Nikolaus Rieber, Michael Kormann, Barbara Koller, Adelbert Roscher, Dirk Roos, Matthias Griese, Oliver Eickelberg, Gerd Döring, Marcus A Mall & Dominik Hartl |
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| 520 | |a Recent studies have shown that neutrophil extracellular traps (NETs) can capture and kill bacteria but may also contribute to chronic inflammation. The mechanisms that trigger NET formation are not yet fully elucidated. Marcos et al. now report that stimulation of the chemokine receptor CXCR, induces NET formation and that NETs are present in airway fluids of individuals with cystic fibrosis. Blocking CXCR2 activation in the lung reduced NET formation and improved lung function in a mouse model of cystic fibrosis. | ||
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