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Impaired skin regeneration and remodeling after cutaneous injury and chemically induced hyperplasia in taps-transgenic mice

Recently, we identified an AP-1-dependent target gene in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated mouse back skin, which encodes a retroviral-like aspartic proteinase (Taps/Asprv1). Taps expression was detected almost exclusively in stratified epithelia of mouse embryos and adult tissues,...

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Main Authors: Hildenbrand, Maike (Author) , Rhiemeier, Verena Margrit (Author) , Hartenstein, Bettina (Author) , Lahrmann, Bernd (Author) , Grabe, Niels (Author) , Angel, Peter (Author) , Heß, Jochen (Author)
Format: Article (Journal)
Language:English
Published: [July 2010]
In: The journal of investigative dermatology
Year: 2010, Volume: 130, Issue: 7, Pages: 1922-1930
ISSN:1523-1747
DOI:10.1038/jid.2010.54
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/jid.2010.54
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0022202X15349149
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Author Notes:Maike Hildenbrand, Verena Rhiemeier, Bettina Hartenstein, Bernd Lahrmann, Niels Grabe, Peter Angel and Jochen Hess

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520 |a Recently, we identified an AP-1-dependent target gene in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated mouse back skin, which encodes a retroviral-like aspartic proteinase (Taps/Asprv1). Taps expression was detected almost exclusively in stratified epithelia of mouse embryos and adult tissues, and enhanced protein levels were present in several non-neoplastic human skin disorders, implicating a crucial role for differentiation and homeostasis of multilayered epithelia. Here, we generated a mouse model in which Taps transgene expression is under the control of the human ubiquitin C promoter (UBC-Taps). Although no obvious phenotype was observed in normal skin development and homeostasis, these mice showed a significant delay in cutaneous wound closure compared with control animals. Shortly after re-epithelialization, we found an increase in keratinocytes in the stratum granulosum, which express Filaggrin, a late differentiation marker. A hypergranulosum-like phenotype with increased numbers of Filaggrin-positive keratinocytes was also observed in UBC-Taps mice after administration of TPA. In summary, these data show that aberrant Taps expression causes impaired skin regeneration and skin remodeling after cutaneous injury and chemically induced hyperplasia. 
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