First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases
Despite progress in treatment, progressive non-small cell lung cancer (NSCLC) still limits survival dramatically, and novel therapeutic compounds are needed. Initial investigations suggest that artesunate (ART), an antimalarial drug, has antiproliferative capacities. However, antiinvasive and antime...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
19 July 2010
|
| In: |
International journal of cancer
Year: 2010, Jahrgang: 127, Heft: 6, Pages: 1475-1485 |
| ISSN: | 1097-0215 |
| DOI: | 10.1002/ijc.25315 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/ijc.25315 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.25315 
|
| Verfasserangaben: | Suhail Ahmed Kabeer Rasheed, Thomas Efferth, Irfan Ahmed Asangani and Heike Allgayer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1844975339 | ||
| 003 | DE-627 | ||
| 005 | 20230710134810.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230510s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/ijc.25315 |2 doi | |
| 035 | |a (DE-627)1844975339 | ||
| 035 | |a (DE-599)KXP1844975339 | ||
| 035 | |a (OCoLC)1389805734 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Rasheed, Suhail Ahmed Kabeer |d 1978- |e VerfasserIn |0 (DE-588)1012748405 |0 (DE-627)70490540X |0 (DE-576)343620189 |4 aut | |
| 245 | 1 | 0 | |a First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases |c Suhail Ahmed Kabeer Rasheed, Thomas Efferth, Irfan Ahmed Asangani and Heike Allgayer |
| 264 | 1 | |c 19 July 2010 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 10.05.2023 | ||
| 520 | |a Despite progress in treatment, progressive non-small cell lung cancer (NSCLC) still limits survival dramatically, and novel therapeutic compounds are needed. Initial investigations suggest that artesunate (ART), an antimalarial drug, has antiproliferative capacities. However, antiinvasive and antimetastatic properties of ART in cancer have never been explored. Therefore, this first study was performed to (i) investigate if ART is able to inhibit invasion and metastasis in NSCLC and (ii) to identify first molecular targets and mechanisms mediating this ability. ART significantly impaired matrigel invasion of 6 NSCLC cell lines and inhibited urokinase-type plasminogen activator (u-PA) activity, -protein and -mRNA expression. Furthermore, in a PCR-metastasis array, ART inhibited the expression of several matrix metalloproteinases (MMPs), especially MMP-2 and MMP-7 mRNA/protein. In luciferase reporter assays, ART downregulated MMP-2-, MMP-7- and u-PA-promoter/-enhancer activity, in parallel to AP-1- and NF-kB-transactivation. Si-RNA knockdown of u-PA, MMP-2 and MMP-7 abolished ART's ability to inhibit invasion, confirming their role as essential mediators. In vivo, ART significantly impaired primary tumor growth and metastasis in the chicken embryo metastasis (CAM) model. In conclusion, this is the first study to show that ART considerably suppresses invasion and metastasis in NSCLC, specifically targeting transcription of u-PA, MMP-2 and MMP-7, prompting immediate studies on ART as a novel therapeutic in NSCLC. | ||
| 650 | 4 | |a artesunate | |
| 650 | 4 | |a metastasis | |
| 650 | 4 | |a non-small cell lung cancer | |
| 700 | 1 | |a Efferth, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Asangani, Irfan A. |d 1978- |e VerfasserIn |0 (DE-588)141337710 |0 (DE-627)703950835 |0 (DE-576)323094635 |4 aut | |
| 700 | 1 | |a Allgayer, Heike |d 1969- |e VerfasserIn |0 (DE-588)1024987884 |0 (DE-627)720854466 |0 (DE-576)369805003 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of cancer |d Bognor Regis : Wiley-Liss, 1966 |g 127(2010), 6 vom: Juli, Seite 1475-1485 |h Online-Ressource |w (DE-627)269532781 |w (DE-600)1474822-8 |w (DE-576)079876129 |x 1097-0215 |7 nnas |a First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases |
| 773 | 1 | 8 | |g volume:127 |g year:2010 |g number:6 |g month:07 |g pages:1475-1485 |g extent:11 |a First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases |
| 856 | 4 | 0 | |u https://doi.org/10.1002/ijc.25315 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.25315 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230510 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 1024987884 |a Allgayer, Heike |m 1024987884:Allgayer, Heike |d 60000 |d 61800 |d 60000 |e 60000PA1024987884 |e 61800PA1024987884 |e 60000PA1024987884 |k 0/60000/ |k 1/60000/61800/ |k 0/60000/ |p 4 |y j | ||
| 998 | |g 141337710 |a Asangani, Irfan A. |m 141337710:Asangani, Irfan A. |d 60000 |e 60000PA141337710 |k 0/60000/ |p 3 | ||
| 998 | |g 1012748405 |a Rasheed, Suhail Ahmed Kabeer |m 1012748405:Rasheed, Suhail Ahmed Kabeer |d 60000 |e 60000PR1012748405 |k 0/60000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1844975339 |e 4320319540 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 10.05.2023"],"recId":"1844975339","language":["eng"],"title":[{"title":"First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases","title_sort":"First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases"}],"person":[{"given":"Suhail Ahmed Kabeer","family":"Rasheed","role":"aut","roleDisplay":"VerfasserIn","display":"Rasheed, Suhail Ahmed Kabeer"},{"family":"Efferth","given":"Thomas","display":"Efferth, Thomas","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Irfan A.","family":"Asangani","role":"aut","display":"Asangani, Irfan A.","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Allgayer, Heike","given":"Heike","family":"Allgayer"}],"physDesc":[{"extent":"11 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1097-0215"],"zdb":["1474822-8"],"eki":["269532781"],"doi":["10.1002/(ISSN)1097-0215"]},"origin":[{"publisher":"Wiley-Liss","dateIssuedKey":"1966","dateIssuedDisp":"1966-","publisherPlace":"Bognor Regis"}],"titleAlt":[{"title":"Predictive oncology"}],"part":{"extent":"11","volume":"127","text":"127(2010), 6 vom: Juli, Seite 1475-1485","pages":"1475-1485","issue":"6","year":"2010"},"titleTranslated":[{"translated":"Journal international du cancer"}],"pubHistory":["1.1966 -"],"corporate":[{"role":"isb","display":"International Union against Cancer","roleDisplay":"Herausgebendes Organ"}],"language":["eng"],"recId":"269532781","disp":"First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteasesInternational journal of cancer","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 28.02.08","Darin: Predictive oncology"],"title":[{"title_sort":"International journal of cancer","subtitle":"publication of the International Union against Cancer (UICC) = Journal international du cancer","title":"International journal of cancer"}]}],"origin":[{"dateIssuedKey":"2010","dateIssuedDisp":"19 July 2010"}],"id":{"eki":["1844975339"],"doi":["10.1002/ijc.25315"]},"name":{"displayForm":["Suhail Ahmed Kabeer Rasheed, Thomas Efferth, Irfan Ahmed Asangani and Heike Allgayer"]}} | ||
| SRT | |a RASHEEDSUHFIRSTEVIDE1920 | ||