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Transcriptional down-regulation of the Wnt antagonist SFRP1 in haematopoietic cells of patients with different risk types of MDS

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Secreted frizzled related protein 1 (SFRP1) is an extracellular antagonist of the Wnt signalling pathway that plays an important role in the pathogenesis of solid tumours and haematopoietic malignancies. SFRP1 has been observed to be transcriptionally down-regulated due to hypermethylation in acute...

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Main Authors: Reins, Jana (Author) , Mossner, Maximilian (Author) , Neumann, Martin (Author) , Platzbecker, Uwe (Author) , Schumann, Christiane (Author) , Thiel, Eckhard (Author) , Hofmann, Wolf-Karsten (Author)
Format: Article (Journal)
Language:English
Published: 14 May 2010
In: Leukemia research
Year: 2010, Volume: 34, Issue: 12, Pages: 1610-1616
ISSN:1873-5835
DOI:10.1016/j.leukres.2010.04.013
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.leukres.2010.04.013
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0145212610002171
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Author Notes:Jana Reins, Maximilian Mossner, Martin Neumann, Uwe Platzbecker, Christiane Schumann, Eckhard Thiel, Wolf-Karsten Hofmann
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Gene expression pattern of ESPL1, PTTG1 and PTTG1IP can potentially predict response to TKI first-line treatment of patients with newly diagnosed CML by Christiani, Eva (Author) , Naumann, Nicole (Author) , Weiß, Christel (Author) , Spiess, Birgit (Author) , Kleiner, Helga (Author) , Fabarius, Alice (Author) , Hofmann, Wolf-Karsten (Author) , Saußele, Susanne (Author) , Seifarth, Wolfgang (Author) ,


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