Rhizoma coptidis inhibits LPS-induced MCP-1/CCL2 production in murine macrophages via an AP-1 and NFk B-dependent pathway
Introduction. The Chinese extract Rhizoma coptidis is well known for its anti-inflammatory, antioxidative, antiviral, and antimicrobial activity. The exact mechanisms of action are not fully understood. Methods. We examined the effect of the extract and its main compound, berberine, on LPS-induced i...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
21 Jun 2010
|
| In: |
Mediators of inflammation
Year: 2010, Jahrgang: 2010, Pages: 1-9 |
| ISSN: | 1466-1861 |
| DOI: | 10.1155/2010/194896 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1155/2010/194896 Verlag, lizenzpflichtig, Volltext: https://www.hindawi.com/journals/mi/2010/194896/ 
|
| Verfasserangaben: | Andrew Remppis, Florian Bea, Henry Johannes Greten, Annette Buttler, Hongjie Wang, Qianxing Zhou, Michael R. Preusch, Ronny Enk, Robert Ehehalt, Hugo Katus, and Erwin Blessing |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1845302869 | ||
| 003 | DE-627 | ||
| 005 | 20230710134248.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230512s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1155/2010/194896 |2 doi | |
| 035 | |a (DE-627)1845302869 | ||
| 035 | |a (DE-599)KXP1845302869 | ||
| 035 | |a (OCoLC)1389805641 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Remppis, Bjoern-Andrew |d 1961- |e VerfasserIn |0 (DE-588)112494986 |0 (DE-627)509446701 |0 (DE-576)289733294 |4 aut | |
| 245 | 1 | 0 | |a Rhizoma coptidis inhibits LPS-induced MCP-1/CCL2 production in murine macrophages via an AP-1 and NFk B-dependent pathway |c Andrew Remppis, Florian Bea, Henry Johannes Greten, Annette Buttler, Hongjie Wang, Qianxing Zhou, Michael R. Preusch, Ronny Enk, Robert Ehehalt, Hugo Katus, and Erwin Blessing |
| 246 | 3 | 0 | |a one two |
| 246 | 3 | 3 | |a Rhizoma coptidis inhibits LPS-induced MCP-1/CCL2 production in murine macrophages via an AP-1 and NF kappa B-dependent pathway |
| 264 | 1 | |c 21 Jun 2010 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.05.2023 | ||
| 520 | |a Introduction. The Chinese extract Rhizoma coptidis is well known for its anti-inflammatory, antioxidative, antiviral, and antimicrobial activity. The exact mechanisms of action are not fully understood. Methods. We examined the effect of the extract and its main compound, berberine, on LPS-induced inflammatory activity in a murine macrophage cell line. RAW 264.7 cells were stimulated with LPS and incubated with either Rhizoma coptidis extract or berberine. Activation of AP-1 and NF B was analyzed in nuclear extracts, secretion of MCP-1/CCL2 was measured in supernatants. Results. Incubation with Rhizoma coptidis and berberine strongly inhibited LPS-induced monocyte chemoattractant protein (MCP)-1 production in RAW cells. Activation of the transcription factors AP-1 and NF B was inhibited by Rhizoma coptidis in a dose- and time-dependent fashion. Conclusions. Rhizoma coptidis extract inhibits LPS-induced MCP-1/CCL2 production in vitro via an AP-1 and NF B-dependent pathway. Anti-inflammatory action of the extract is mediated mainly by its alkaloid compound berberine. | ||
| 700 | 1 | |a Bea, Florian |d 1969- |e VerfasserIn |0 (DE-588)1052114318 |0 (DE-627)787838276 |0 (DE-576)407871489 |4 aut | |
| 700 | 1 | |a Greten, Henry Johannes |e VerfasserIn |4 aut | |
| 700 | 1 | |a Buttler, Annette |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wang, Hongjie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zhou, Qianxing |e VerfasserIn |4 aut | |
| 700 | 1 | |a Preusch, Michael R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Enk, Ronny |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ehehalt, Robert |e VerfasserIn |4 aut | |
| 700 | 1 | |a Katus, Hugo |d 1951- |e VerfasserIn |0 (DE-588)108916618 |0 (DE-627)577155040 |0 (DE-576)289625076 |4 aut | |
| 700 | 1 | |a Blessing, Erwin |d 1966- |e VerfasserIn |0 (DE-588)1054407673 |0 (DE-627)791478661 |0 (DE-576)410244570 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Mediators of inflammation |d [Hoboken, NJ] : Wiley, 1992 |g 2010(2010) vom: Juni, Artikel-ID e194896, Seite 1-9 |h Online-Ressource |w (DE-627)320467384 |w (DE-600)2008065-7 |w (DE-576)273878204 |x 1466-1861 |7 nnas |a Rhizoma coptidis inhibits LPS-induced MCP-1/CCL2 production in murine macrophages via an AP-1 and NFk B-dependent pathway |
| 773 | 1 | 8 | |g volume:2010 |g year:2010 |g month:06 |g elocationid:e194896 |g pages:1-9 |g extent:9 |a Rhizoma coptidis inhibits LPS-induced MCP-1/CCL2 production in murine macrophages via an AP-1 and NFk B-dependent pathway |
| 856 | 4 | 0 | |u https://doi.org/10.1155/2010/194896 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.hindawi.com/journals/mi/2010/194896/ |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230512 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 1054407673 |a Blessing, Erwin |m 1054407673:Blessing, Erwin |d 50000 |e 50000PB1054407673 |k 0/50000/ |p 11 |y j | ||
| 998 | |g 108916618 |a Katus, Hugo |m 108916618:Katus, Hugo |d 910000 |d 910100 |e 910000PK108916618 |e 910100PK108916618 |k 0/910000/ |k 1/910000/910100/ |p 10 | ||
| 998 | |g 1052114318 |a Bea, Florian |m 1052114318:Bea, Florian |d 50000 |e 50000PB1052114318 |k 0/50000/ |p 2 | ||
| 999 | |a KXP-PPN1845302869 |e 4321221412 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1845302869","titleAlt":[{"title":"Rhizoma coptidis inhibits LPS-induced MCP-1/CCL2 production in murine macrophages via an AP-1 and NF kappa B-dependent pathway"}],"origin":[{"dateIssuedDisp":"21 Jun 2010","dateIssuedKey":"2010"}],"physDesc":[{"extent":"9 S."}],"name":{"displayForm":["Andrew Remppis, Florian Bea, Henry Johannes Greten, Annette Buttler, Hongjie Wang, Qianxing Zhou, Michael R. Preusch, Ronny Enk, Robert Ehehalt, Hugo Katus, and Erwin Blessing"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1155/2010/194896"],"eki":["1845302869"]},"person":[{"given":"Bjoern-Andrew","role":"aut","family":"Remppis","display":"Remppis, Bjoern-Andrew"},{"given":"Florian","role":"aut","display":"Bea, Florian","family":"Bea"},{"family":"Greten","display":"Greten, Henry Johannes","role":"aut","given":"Henry Johannes"},{"display":"Buttler, Annette","family":"Buttler","role":"aut","given":"Annette"},{"display":"Wang, Hongjie","family":"Wang","given":"Hongjie","role":"aut"},{"display":"Zhou, Qianxing","family":"Zhou","given":"Qianxing","role":"aut"},{"family":"Preusch","display":"Preusch, Michael R.","role":"aut","given":"Michael R."},{"role":"aut","given":"Ronny","family":"Enk","display":"Enk, Ronny"},{"given":"Robert","role":"aut","display":"Ehehalt, Robert","family":"Ehehalt"},{"given":"Hugo","role":"aut","display":"Katus, Hugo","family":"Katus"},{"display":"Blessing, Erwin","family":"Blessing","given":"Erwin","role":"aut"}],"title":[{"title":"Rhizoma coptidis inhibits LPS-induced MCP-1/CCL2 production in murine macrophages via an AP-1 and NFk B-dependent pathway","title_sort":"Rhizoma coptidis inhibits LPS-induced MCP-1/CCL2 production in murine macrophages via an AP-1 and NFk B-dependent pathway"}],"language":["eng"],"relHost":[{"id":{"eki":["320467384"],"doi":["10.1155/MI"],"zdb":["2008065-7"],"issn":["1466-1861"]},"type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"[Hoboken, NJ] ; London ; Sylvania, Ohio","dateIssuedDisp":"2024-","dateIssuedKey":"2024","publisher":"Wiley ; Taylor & Francis ; Hindawi Publishing Corp."}],"recId":"320467384","pubHistory":["1.1992-"],"note":["Gesehen am 29.01.2025"],"part":{"year":"2010","text":"2010(2010) vom: Juni, Artikel-ID e194896, Seite 1-9","extent":"9","volume":"2010","pages":"1-9"},"language":["eng"],"disp":"Rhizoma coptidis inhibits LPS-induced MCP-1/CCL2 production in murine macrophages via an AP-1 and NFk B-dependent pathwayMediators of inflammation","title":[{"title":"Mediators of inflammation","title_sort":"Mediators of inflammation"}]}],"note":["Gesehen am 12.05.2023"]} | ||
| SRT | |a REMPPISBJORHIZOMACOP2120 | ||