Cerebrospinal fluid pressure in glaucoma: a prospective study
Purpose - To assess whether a low cerebrospinal fluid pressure (CSF-P) is associated with open-angle glaucoma in eyes with normal intraocular pressure (IOP). - Design - Prospective, interventional study. - Participants - The study included 43 patients with open-angle glaucoma (14 with a normal IOP,...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 2010
|
| In: |
Ophthalmology
Year: 2010, Jahrgang: 117, Heft: 2, Pages: 259-266 |
| ISSN: | 1549-4713 |
| DOI: | 10.1016/j.ophtha.2009.06.058 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ophtha.2009.06.058 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0161642009007337 
|
| Verfasserangaben: | Ruojin Ren, Jost B. Jonas, Guoghong Tian, Yi Zhen, Ke Ma, Shuning Li, Hongtao Wang, Bin Li, Xiaojun Zhang, Ningli Wang |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 184530389X | ||
| 003 | DE-627 | ||
| 005 | 20230710134241.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230512s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ophtha.2009.06.058 |2 doi | |
| 035 | |a (DE-627)184530389X | ||
| 035 | |a (DE-599)KXP184530389X | ||
| 035 | |a (OCoLC)1389805634 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Ren, Ruojin |e VerfasserIn |0 (DE-588)1159652260 |0 (DE-627)1022309382 |0 (DE-576)505162989 |4 aut | |
| 245 | 1 | 0 | |a Cerebrospinal fluid pressure in glaucoma |b a prospective study |c Ruojin Ren, Jost B. Jonas, Guoghong Tian, Yi Zhen, Ke Ma, Shuning Li, Hongtao Wang, Bin Li, Xiaojun Zhang, Ningli Wang |
| 264 | 1 | |c February 2010 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar 6. Dezember 2009 | ||
| 500 | |a Gesehen am 12.05.2023 | ||
| 520 | |a Purpose - To assess whether a low cerebrospinal fluid pressure (CSF-P) is associated with open-angle glaucoma in eyes with normal intraocular pressure (IOP). - Design - Prospective, interventional study. - Participants - The study included 43 patients with open-angle glaucoma (14 with a normal IOP, and 29 with an elevated IOP) and 71 subjects without glaucoma. - Interventions - All patients underwent standardized ophthalmologic and neurologic examinations and measurement of lumbar CSF-P. - Main Outcome Measures - Cerebrospinal fluid pressure and IOP. - Results - Lumbar CSF-P was significantly (P<0.001) lower in the normal IOP glaucoma group (9.5±2.2 mmHg) than in the high IOP glaucoma group (11.7±2.7 mmHg) or the control group (12.9±1.9 mmHg). The trans-lamina cribrosa pressure difference (IOP minus CSF-P) was significantly (P<0.001) higher in the normal IOP glaucoma group (6.6±3.6 mmHg) and the high-IOP glaucoma group (12.5±4.1 mmHg) than in the control group (1.4±1.7 mmHg). The extent of glaucomatous visual field loss was negatively correlated with the height of the CSF-P and positively correlated with the trans-lamina cribrosa pressure difference. In the control group, CSF-P was significantly correlated with both systolic blood pressure (P = 0.04) and IOP (P<0.001). The trans-lamina cribrosa pressure difference was not significantly associated with blood pressure (P = 0.97). - Conclusions - In open-angle glaucoma with normal IOP, CSF-P is abnormally low, leading to an abnormally high trans-lamina cribrosa pressure difference. Pathogenetically, a low CSF-P in normal-IOP glaucoma may be similar to a high IOP in high-IOP glaucoma. Consequently, the glaucomatous visual field defect is positively correlated with the trans-lamina cribrosa pressure difference and inversely correlated with the CSF-P. In nonglaucomatous subjects, CSF-P, blood pressure, and IOP are significantly associated with each other. - Financial Disclosure(s) - The authors have no proprietary or commercial interest in any of the materials discussed in this article. | ||
| 700 | 1 | |a Jonas, Jost B. |d 1958- |e VerfasserIn |0 (DE-588)1028286732 |0 (DE-627)730536823 |0 (DE-576)37578537X |4 aut | |
| 700 | 1 | |a Tian, Guoghong |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zhen, Yi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ma, Ke |e VerfasserIn |4 aut | |
| 700 | 1 | |a Li, Shuning |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wang, Hongtao |e VerfasserIn |4 aut | |
| 700 | 1 | |a Li, Bin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zhang, Xiaojun |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wang, Ningli |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Ophthalmology |d Amsterdam [u.a.] : Elsevier, 1978 |g 117(2010), 2 vom: Feb., Seite 259-266 |h Online-Ressource |w (DE-627)320526941 |w (DE-600)2015287-5 |w (DE-576)121465691 |x 1549-4713 |7 nnas |a Cerebrospinal fluid pressure in glaucoma a prospective study |
| 773 | 1 | 8 | |g volume:117 |g year:2010 |g number:2 |g month:02 |g pages:259-266 |g extent:8 |a Cerebrospinal fluid pressure in glaucoma a prospective study |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ophtha.2009.06.058 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0161642009007337 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230512 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 1028286732 |a Jonas, Jost B. |m 1028286732:Jonas, Jost B. |d 60000 |d 61700 |e 60000PJ1028286732 |e 61700PJ1028286732 |k 0/60000/ |k 1/60000/61700/ |p 2 | ||
| 999 | |a KXP-PPN184530389X |e 4321226996 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"title":[{"title_sort":"Ophthalmology","subtitle":"journal of the American Academy of Ophthalmology","title":"Ophthalmology"}],"part":{"year":"2010","text":"117(2010), 2 vom: Feb., Seite 259-266","volume":"117","extent":"8","pages":"259-266","issue":"2"},"language":["eng"],"pubHistory":["85.1978 -"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"320526941","origin":[{"dateIssuedKey":"1978","dateIssuedDisp":"1978-","publisher":"Elsevier ; Acad.","publisherPlace":"Amsterdam [u.a.] ; San Francisco, Calif."}],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Cerebrospinal fluid pressure in glaucoma a prospective studyOphthalmology","id":{"eki":["320526941"],"zdb":["2015287-5"],"issn":["1549-4713"]},"corporate":[{"display":"American Academy of Ophthalmology","role":"isb"}],"note":["Gesehen am 15.01.20"]}],"note":["Online verfügbar 6. Dezember 2009","Gesehen am 12.05.2023"],"id":{"doi":["10.1016/j.ophtha.2009.06.058"],"eki":["184530389X"]},"physDesc":[{"extent":"8 S."}],"origin":[{"dateIssuedKey":"2010","dateIssuedDisp":"February 2010"}],"recId":"184530389X","type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"display":"Ren, Ruojin","role":"aut","given":"Ruojin","family":"Ren"},{"role":"aut","given":"Jost B.","display":"Jonas, Jost B.","family":"Jonas"},{"family":"Tian","display":"Tian, Guoghong","role":"aut","given":"Guoghong"},{"family":"Zhen","role":"aut","given":"Yi","display":"Zhen, Yi"},{"display":"Ma, Ke","given":"Ke","role":"aut","family":"Ma"},{"display":"Li, Shuning","role":"aut","given":"Shuning","family":"Li"},{"family":"Wang","given":"Hongtao","role":"aut","display":"Wang, Hongtao"},{"display":"Li, Bin","role":"aut","given":"Bin","family":"Li"},{"family":"Zhang","given":"Xiaojun","role":"aut","display":"Zhang, Xiaojun"},{"display":"Wang, Ningli","given":"Ningli","role":"aut","family":"Wang"}],"name":{"displayForm":["Ruojin Ren, Jost B. Jonas, Guoghong Tian, Yi Zhen, Ke Ma, Shuning Li, Hongtao Wang, Bin Li, Xiaojun Zhang, Ningli Wang"]},"language":["eng"],"title":[{"title_sort":"Cerebrospinal fluid pressure in glaucoma","title":"Cerebrospinal fluid pressure in glaucoma","subtitle":"a prospective study"}]} | ||
| SRT | |a RENRUOJINJCEREBROSPI2010 | ||