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Gene Deletion Mutants Reveal a Role for Semaphorin Receptors of the Plexin-B Family in Mechanisms Underlying Corticogenesis

Semaphorins and their receptors, plexins, are emerging as key regulators of various aspects of neural and nonneural development. Semaphorin 4D (Sema4D) and B-type plexins demonstrate distinct expression patterns over critical time windows during the development of the murine neocortex. Here, analysi...

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Main Authors: Hirschberg, Alexandra (Author) , Deng, Suhua (Author) , Korostylev, Alexander (Author) , Paldy, Eszter (Author) , Costa, M. R. (Author) , Worzfeld, Thomas (Author) , Vodrazka, Peter (Author) , Wizenmann, A. (Author) , Götz, M. (Author) , Offermanns, Stefan (Author) , Kuner, Ruprecht (Author)
Format: Article (Journal)
Language:English
Published: [2010]
In: Molecular and cellular biology
Year: 2010, Volume: 30, Issue: 3, Pages: 764-780
ISSN:0270-7306
DOI:10.1128/MCB.01458-09
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1128/MCB.01458-09
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Author Notes:A. Hirschberg, S. Deng, A. Korostylev, E. Paldy, M. R. Costa, T. Worzfeld, P. Vodrazka, A. Wizenmann, M. Götz, S. Offermanns, R. Kuner
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Summary:Semaphorins and their receptors, plexins, are emerging as key regulators of various aspects of neural and nonneural development. Semaphorin 4D (Sema4D) and B-type plexins demonstrate distinct expression patterns over critical time windows during the development of the murine neocortex. Here, analysis of mice genetically lacking plexin-B1 or plexin-B2 revealed the significance of Sema4D-plexin-B signaling in cortical development. Deficiency of plexin-B2 resulted in abnormal cortical layering and defective migration and differentiation of several subtypes of cortical neurons, including Cajal-Retzius cells, GABAergic interneurons, and principal cells in vivo. In contrast, a lack of plexin-B1 did not impact on cortical development in vivo. In various ex vivo assays on embryonic forebrain, Sema4D enhanced the radial and tangential migration of developing neurons in a plexin-B2-dependent manner. These results suggest that Sema4D-plexin-B2 interactions regulate mechanisms underlying cell specification, differentiation, and migration during corticogenesis.
Item Description:Published online: 20 Mar 2023
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Gesehen am 15.05.2023
Physical Description:Online Resource
ISSN:0270-7306
DOI:10.1128/MCB.01458-09

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