Gene Deletion Mutants Reveal a Role for Semaphorin Receptors of the Plexin-B Family in Mechanisms Underlying Corticogenesis
Semaphorins and their receptors, plexins, are emerging as key regulators of various aspects of neural and nonneural development. Semaphorin 4D (Sema4D) and B-type plexins demonstrate distinct expression patterns over critical time windows during the development of the murine neocortex. Here, analysi...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[2010]
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| In: |
Molecular and cellular biology
Year: 2010, Jahrgang: 30, Heft: 3, Pages: 764-780 |
| ISSN: | 0270-7306 |
| DOI: | 10.1128/MCB.01458-09 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1128/MCB.01458-09
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| Verfasserangaben: | A. Hirschberg, S. Deng, A. Korostylev, E. Paldy, M. R. Costa, T. Worzfeld, P. Vodrazka, A. Wizenmann, M. Götz, S. Offermanns, R. Kuner |
MARC
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| 245 | 1 | 0 | |a Gene Deletion Mutants Reveal a Role for Semaphorin Receptors of the Plexin-B Family in Mechanisms Underlying Corticogenesis |c A. Hirschberg, S. Deng, A. Korostylev, E. Paldy, M. R. Costa, T. Worzfeld, P. Vodrazka, A. Wizenmann, M. Götz, S. Offermanns, R. Kuner |
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| 520 | |a Semaphorins and their receptors, plexins, are emerging as key regulators of various aspects of neural and nonneural development. Semaphorin 4D (Sema4D) and B-type plexins demonstrate distinct expression patterns over critical time windows during the development of the murine neocortex. Here, analysis of mice genetically lacking plexin-B1 or plexin-B2 revealed the significance of Sema4D-plexin-B signaling in cortical development. Deficiency of plexin-B2 resulted in abnormal cortical layering and defective migration and differentiation of several subtypes of cortical neurons, including Cajal-Retzius cells, GABAergic interneurons, and principal cells in vivo. In contrast, a lack of plexin-B1 did not impact on cortical development in vivo. In various ex vivo assays on embryonic forebrain, Sema4D enhanced the radial and tangential migration of developing neurons in a plexin-B2-dependent manner. These results suggest that Sema4D-plexin-B2 interactions regulate mechanisms underlying cell specification, differentiation, and migration during corticogenesis. | ||
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