Buchumschlag

Abrupt transitions between prefrontal neural ensemble states accompany behavioral transitions during rule learning

One of the most intriguing aspects of adaptive behavior involves the inference of regularities and rules in ever-changing environments. Rules are often deduced through evidence-based learning which relies on the prefrontal cortex (PFC). This is a highly dynamic process, evolving trial by trial and t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Durstewitz, Daniel (VerfasserIn) , Vittoz, Nicole M. (VerfasserIn) , Floresco, Stan B. (VerfasserIn) , Seamans, Jeremy K. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 12 May 2010
In: Neuron
Year: 2010, Jahrgang: 66, Heft: 3, Pages: 438-448
ISSN:1097-4199
DOI:10.1016/j.neuron.2010.03.029
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neuron.2010.03.029
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0896627310002321
Volltext
Verfasserangaben:Daniel Durstewitz, Nicole M. Vittoz, Stan B. Floresco, and Jeremy K. Seamans

MARC

LEADER 00000caa a2200000 c 4500
001 184539299X
003 DE-627
005 20230710133731.0
007 cr uuu---uuuuu
008 230515s2010 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.neuron.2010.03.029  |2 doi 
035 |a (DE-627)184539299X 
035 |a (DE-599)KXP184539299X 
035 |a (OCoLC)1389794174 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Durstewitz, Daniel  |d 1967-  |e VerfasserIn  |0 (DE-588)12042021X  |0 (DE-627)080664008  |0 (DE-576)174757050  |4 aut 
245 1 0 |a Abrupt transitions between prefrontal neural ensemble states accompany behavioral transitions during rule learning  |c Daniel Durstewitz, Nicole M. Vittoz, Stan B. Floresco, and Jeremy K. Seamans 
264 1 |c 12 May 2010 
300 |a 11 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 15.05.2023 
520 |a One of the most intriguing aspects of adaptive behavior involves the inference of regularities and rules in ever-changing environments. Rules are often deduced through evidence-based learning which relies on the prefrontal cortex (PFC). This is a highly dynamic process, evolving trial by trial and therefore may not be adequately captured by averaging single-unit responses over numerous repetitions. Here, we employed advanced statistical techniques to visualize the trajectories of ensembles of simultaneously recorded medial PFC neurons on a trial-by-trial basis as rats deduced a novel rule in a set-shifting task. Neural populations formed clearly distinct and lasting representations of familiar and novel rules by entering unique network states. During rule acquisition, the recorded ensembles often exhibited abrupt transitions, rather than evolving continuously, in tight temporal relation to behavioral performance shifts. These results support the idea that rule learning is an evidence-based decision process, perhaps accompanied by moments of sudden insight. 
650 4 |a SYSNEURO 
700 1 |a Vittoz, Nicole M.  |e VerfasserIn  |4 aut 
700 1 |a Floresco, Stan B.  |e VerfasserIn  |4 aut 
700 1 |a Seamans, Jeremy K.  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Neuron  |d [Cambridge, Mass.] : Cell Press, 1988  |g 66(2010), 3 vom: Mai, Seite 438-448  |h Online-Ressource  |w (DE-627)320416062  |w (DE-600)2001944-0  |w (DE-576)090881354  |x 1097-4199  |7 nnas  |a Abrupt transitions between prefrontal neural ensemble states accompany behavioral transitions during rule learning 
773 1 8 |g volume:66  |g year:2010  |g number:3  |g month:05  |g pages:438-448  |g extent:11  |a Abrupt transitions between prefrontal neural ensemble states accompany behavioral transitions during rule learning 
856 4 0 |u https://doi.org/10.1016/j.neuron.2010.03.029  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S0896627310002321  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20230515 
993 |a Article 
994 |a 2010 
998 |g 12042021X  |a Durstewitz, Daniel  |m 12042021X:Durstewitz, Daniel  |d 130000  |e 130000PD12042021X  |k 0/130000/  |p 1  |x j 
999 |a KXP-PPN184539299X  |e 4322087493 
BIB |a Y 
SER |a journal 
JSO |a {"name":{"displayForm":["Daniel Durstewitz, Nicole M. Vittoz, Stan B. Floresco, and Jeremy K. Seamans"]},"person":[{"family":"Durstewitz","display":"Durstewitz, Daniel","role":"aut","given":"Daniel"},{"family":"Vittoz","given":"Nicole M.","role":"aut","display":"Vittoz, Nicole M."},{"display":"Floresco, Stan B.","given":"Stan B.","role":"aut","family":"Floresco"},{"family":"Seamans","given":"Jeremy K.","role":"aut","display":"Seamans, Jeremy K."}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"12 May 2010","dateIssuedKey":"2010"}],"recId":"184539299X","relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1097-4199"],"zdb":["2001944-0"],"eki":["320416062"]},"disp":"Abrupt transitions between prefrontal neural ensemble states accompany behavioral transitions during rule learningNeuron","note":["Gesehen am 02.04.25"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"320416062","origin":[{"publisherPlace":"[Cambridge, Mass.] ; New York, NY","dateIssuedKey":"1988","publisher":"Cell Press ; Elsevier","dateIssuedDisp":"1988-"}],"title":[{"title":"Neuron","title_sort":"Neuron"}],"language":["eng"],"part":{"volume":"66","year":"2010","text":"66(2010), 3 vom: Mai, Seite 438-448","issue":"3","pages":"438-448","extent":"11"},"pubHistory":["1.1988 -"]}],"note":["Gesehen am 15.05.2023"],"physDesc":[{"extent":"11 S."}],"id":{"eki":["184539299X"],"doi":["10.1016/j.neuron.2010.03.029"]},"language":["eng"],"title":[{"title_sort":"Abrupt transitions between prefrontal neural ensemble states accompany behavioral transitions during rule learning","title":"Abrupt transitions between prefrontal neural ensemble states accompany behavioral transitions during rule learning"}]} 
SRT |a DURSTEWITZABRUPTTRAN1220 

Ähnliche Einträge