Hematopoietic stem cell boost for persistent neutropenia after CAR T-cell therapy: a GLA/DRST study
Hematotoxicity after chimeric antigen receptor (CAR) T-cell therapy is associated with infection and death but management remains unclear. We report results of 31 patients receiving hematopoietic stem cell boost (HSCB; 30 autologous, 1 allogeneic) for either sustained severe neutropenia of grade 4 (...
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
20 February 2023
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| In: |
Blood advances
Year: 2023, Jahrgang: 7, Heft: 4, Pages: 555-559 |
| ISSN: | 2473-9537 |
| DOI: | 10.1182/bloodadvances.2022008042 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/bloodadvances.2022008042 Verlag, lizenzpflichtig, Volltext: https://ashpublications.org/bloodadvances/article/7/4/555/485535/Hematopoietic-stem-cell-boost-for-persistent 
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| Verfasserangaben: | Nico Gagelmann, Gerald Georg Wulf, Johannes Duell, Bertram Glass, Pearl van Heteren, Bastian von Tresckow, Monika Fischer, Olaf Penack, Francis Ayuk, Herrmann Einsele, Udo Holtick, Julia Thomson, Peter Dreger, and Nicolaus Kröger |
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| 520 | |a Hematotoxicity after chimeric antigen receptor (CAR) T-cell therapy is associated with infection and death but management remains unclear. We report results of 31 patients receiving hematopoietic stem cell boost (HSCB; 30 autologous, 1 allogeneic) for either sustained severe neutropenia of grade 4 (<0.5 × 109/L), sustained moderate neutropenia (≤1.5 × 109/L) and high risk of infection, or neutrophil count ≤2.0 × 109/L and active infection. ... | ||
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