Soft micropillar interfaces of distinct biomechanics govern behaviour of periodontal cells
A soft micropillar extracellular environment of distinct biomechanics is established by fabricating polydimethylsiloxane (PDMS) interfaces with pillar distances of 5, 7, 9 and 11μm and elasticity moduli of 0.6, 1.0 and 3.5 Mega Pascal. To allow for cell adhesion, the biomimetic concept of pillar hea...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2010
|
| In: |
European journal of cell biology
Year: 2010, Jahrgang: 89, Heft: 4, Pages: 315-325 |
| ISSN: | 1618-1298 |
| DOI: | 10.1016/j.ejcb.2009.08.004 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejcb.2009.08.004 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0171933509002933 
|
| Verfasserangaben: | Eva Mussig, Simon Schulz, Joachim P. Spatz, Nelli Ziegler, Pascal Tomakidi, Thorsten Steinberg |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1845612795 | ||
| 003 | DE-627 | ||
| 005 | 20230710133514.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230517s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ejcb.2009.08.004 |2 doi | |
| 035 | |a (DE-627)1845612795 | ||
| 035 | |a (DE-599)KXP1845612795 | ||
| 035 | |a (OCoLC)1389802058 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Wörtche, Eva |d 1975- |e VerfasserIn |0 (DE-588)123019915 |0 (DE-627)706130480 |0 (DE-576)293522995 |4 aut | |
| 245 | 1 | 0 | |a Soft micropillar interfaces of distinct biomechanics govern behaviour of periodontal cells |c Eva Mussig, Simon Schulz, Joachim P. Spatz, Nelli Ziegler, Pascal Tomakidi, Thorsten Steinberg |
| 264 | 1 | |c 2010 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Erstmals am 25 September 2009 online veröffentlicht | ||
| 500 | |a Gesehen am 17.05.2023 | ||
| 520 | |a A soft micropillar extracellular environment of distinct biomechanics is established by fabricating polydimethylsiloxane (PDMS) interfaces with pillar distances of 5, 7, 9 and 11μm and elasticity moduli of 0.6, 1.0 and 3.5 Mega Pascal. To allow for cell adhesion, the biomimetic concept of pillar head fibronectin (FN) biofunctionalisation is applied. This environmental set-up aims at the analysis of favourable conditions for cell behaviour of three periodontal cell-types, here reflected by the establishment of regular cell morphology and optimal collagen gene expression. Biomechanics of these predefined functionalised model surfaces reveal progressive deterioration of regular cell morphology with increasing pillar distance, independent from pillar elasticity and cell type. Analysis of collagen gene expression demonstrates interdependency to the elasticity and the micropattern of the extracellular environment in all cell types under study. The results suggest that biomechanics of the extracellular environment govern tissue-specific cell behaviour in different periodontal cell types. Moreover, they form the basis for the creation of new biomaterials which address distinct cell functions by specific biomechanical properties. | ||
| 650 | 4 | |a biofunctionalisation | |
| 650 | 4 | |a biomechanics | |
| 650 | 4 | |a elasticity | |
| 650 | 4 | |a micropillar interfaces | |
| 650 | 4 | |a periodontium | |
| 650 | 4 | |a polydimethylsiloxane (PDMS) | |
| 700 | 1 | |a Schulz, Simon |d 1977- |e VerfasserIn |0 (DE-588)138299749 |0 (DE-627)601107519 |0 (DE-576)307079473 |4 aut | |
| 700 | 1 | |a Spatz, Joachim P. |d 1969- |e VerfasserIn |0 (DE-588)122582675 |0 (DE-627)08203124X |0 (DE-576)173014771 |4 aut | |
| 700 | 1 | |a Ziegler, Nelli |d 1977- |e VerfasserIn |0 (DE-588)136457185 |0 (DE-627)583298990 |0 (DE-576)279377282 |4 aut | |
| 700 | 1 | |a Tomakidi, Pascal |d 1962- |e VerfasserIn |0 (DE-588)1077112084 |0 (DE-627)836024931 |0 (DE-576)176958371 |4 aut | |
| 700 | 1 | |a Steinberg, Thorsten |e VerfasserIn |0 (DE-588)1076048412 |0 (DE-627)834221195 |0 (DE-576)16561367X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of cell biology |d München : Elsevier, 1998 |g 89(2010), 4 vom: Apr., Seite 315-325 |h Online-Ressource |w (DE-627)334288150 |w (DE-600)2056855-1 |w (DE-576)094661901 |x 1618-1298 |7 nnas |a Soft micropillar interfaces of distinct biomechanics govern behaviour of periodontal cells |
| 773 | 1 | 8 | |g volume:89 |g year:2010 |g number:4 |g month:04 |g pages:315-325 |g extent:11 |a Soft micropillar interfaces of distinct biomechanics govern behaviour of periodontal cells |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ejcb.2009.08.004 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0171933509002933 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230517 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 1076048412 |a Steinberg, Thorsten |m 1076048412:Steinberg, Thorsten |p 6 |y j | ||
| 998 | |g 1077112084 |a Tomakidi, Pascal |m 1077112084:Tomakidi, Pascal |p 5 | ||
| 998 | |g 136457185 |a Ziegler, Nelli |m 136457185:Ziegler, Nelli |p 4 | ||
| 998 | |g 122582675 |a Spatz, Joachim P. |m 122582675:Spatz, Joachim P. |d 120000 |d 120300 |e 120000PS122582675 |e 120300PS122582675 |k 0/120000/ |k 1/120000/120300/ |p 3 | ||
| 998 | |g 138299749 |a Schulz, Simon |m 138299749:Schulz, Simon |p 2 | ||
| 998 | |g 123019915 |a Wörtche, Eva |m 123019915:Wörtche, Eva |p 1 |x j | ||
| 999 | |a KXP-PPN1845612795 |e 4323064128 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"roleDisplay":"VerfasserIn","display":"Wörtche, Eva","role":"aut","family":"Wörtche","given":"Eva"},{"family":"Schulz","given":"Simon","roleDisplay":"VerfasserIn","display":"Schulz, Simon","role":"aut"},{"given":"Joachim P.","family":"Spatz","role":"aut","display":"Spatz, Joachim P.","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Ziegler, Nelli","role":"aut","family":"Ziegler","given":"Nelli"},{"family":"Tomakidi","given":"Pascal","display":"Tomakidi, Pascal","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Thorsten","family":"Steinberg","role":"aut","display":"Steinberg, Thorsten","roleDisplay":"VerfasserIn"}],"title":[{"title_sort":"Soft micropillar interfaces of distinct biomechanics govern behaviour of periodontal cells","title":"Soft micropillar interfaces of distinct biomechanics govern behaviour of periodontal cells"}],"note":["Erstmals am 25 September 2009 online veröffentlicht","Gesehen am 17.05.2023"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1845612795","language":["eng"],"name":{"displayForm":["Eva Mussig, Simon Schulz, Joachim P. Spatz, Nelli Ziegler, Pascal Tomakidi, Thorsten Steinberg"]},"origin":[{"dateIssuedKey":"2010","dateIssuedDisp":"2010"}],"id":{"doi":["10.1016/j.ejcb.2009.08.004"],"eki":["1845612795"]},"physDesc":[{"extent":"11 S."}],"relHost":[{"disp":"Soft micropillar interfaces of distinct biomechanics govern behaviour of periodontal cellsEuropean journal of cell biology","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Fortsetzung der Druck-Ausgabe","Gesehen am 11.05.2021"],"recId":"334288150","language":["eng"],"pubHistory":["Nachgewiesen 75.1998 -"],"titleAlt":[{"title":"EJCB"}],"part":{"issue":"4","pages":"315-325","year":"2010","extent":"11","volume":"89","text":"89(2010), 4 vom: Apr., Seite 315-325"},"title":[{"title_sort":"European journal of cell biology","title":"European journal of cell biology"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"München ; Jena","dateIssuedDisp":"1998-","publisher":"Elsevier ; Urban & Fischer","dateIssuedKey":"1998"}],"id":{"eki":["334288150"],"zdb":["2056855-1"],"issn":["1618-1298"]}}]} | ||
| SRT | |a WOERTCHEEVSOFTMICROP2010 | ||