Analysis of bisphenol-propane in dialyzer and its effect on human body
The effect of trace solvent bisphenol A (BPA) in polyether sulfone hollow fiber membrane Enttex™-16LF (E60) (produced by 3 M) low-throughput dialyzer was tested in this study. Animal experiments were conducted to evaluate its genotoxicity, carcinogenicity, and teratogenicity upon - chronic exposure....
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1. Januar 2023
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| In: |
Materials express
Year: 2023, Jahrgang: 13, Heft: 1, Pages: 170-181 |
| ISSN: | 2158-5857 |
| DOI: | 10.1166/mex.2023.2327 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://dx.doi.org/10.1166/mex.2023.2327
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| Verfasserangaben: | Chen Yun, Xiaofan He, Ting Xie, Ao-Ieong Chi-Wa, Weilong Li, Zhuoheng Song, Mengyun Xiao, Yu Meng, Bo Hu, Baozhang Guan, Lifeng Yang, Mingjun Ye, Huiyi Zeng, Stanislao Morgera, Bernhard Krämer, Wolfganng, Lianghong Yin, Shaodong Luan, Suhua Xu, and Berthold Hocher |
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| 520 | |a The effect of trace solvent bisphenol A (BPA) in polyether sulfone hollow fiber membrane Enttex™-16LF (E60) (produced by 3 M) low-throughput dialyzer was tested in this study. Animal experiments were conducted to evaluate its genotoxicity, carcinogenicity, and teratogenicity upon - chronic exposure. The dialyzer was operated at 200 mL/min and 400 mL/min and coupled with LC-20AT liquid chromatography to detect BPA, which showed that the BPA content was less than 5 μg/kg/d at both flow rates. In animal experiments, the tolerable intake (T.I.) was calculated to - be 0.5 μg/kg/d. With hemodialysis three times per week, the average patient weight was calculated at 70 kg, and the average daily BPA exposure was 0.0306 μg/kg/d. The risk of residual BPA was within the acceptable limit with polyether sulfone membrane Enttex™-16LF - (E60) hollow fiber dialyzer from 3 M, without inducing risk for disability, teratogenicity, or genotoxicity. | ||
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| 650 | 4 | |a Hemodialysis | |
| 650 | 4 | |a Risk Assessment | |
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