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Corpus callosum tissue loss and development of motor and global cognitive impairment: the LADIS study

Objective: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. Methods: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging...

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Main Authors: Frederiksen, Kristian Steen (Author) , Garde, Ellen (Author) , Skimminge, Arnold (Author) , Barkhof, Frederik (Author) , Scheltens, Philip (Author) , Straaten, Elisabeth C. W. van (Author) , Fazekas, Franz (Author) , Bäzner, Hansjörg (Author) , Verdelho, Ana (Author) , Ferro, José M. (Author) , Erkinjuntti, Timo (Author) , Jokinen, Hanna (Author) , Wahlund, Lars-Olof (Author) , O’Brien, John T. (Author) , Basile, Anna M. (Author) , Pantoni, Leonardo (Author) , Inzitari, Domenico (Author) , Waldemar, Gunhild (Author)
Format: Article (Journal)
Language:English
Published: January 19, 2012
In: Dementia and geriatric cognitive disorders
Year: 2012, Volume: 32, Issue: 4, Pages: 279-286
ISSN:1421-9824
DOI:10.1159/000334949
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000334949
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Author Notes:Kristian S. Frederiksen, Ellen Garde, Arnold Skimminge, Frederik Barkhof, Philip Scheltens, Elisabeth C.W. van Straaten, Franz Fazekas, Hansjörg Baezner, Ana Verdelho, José M. Ferro, Timo Erkinjuntti, Hanna Jokinen, Lars-Olof Wahlund, John T. O’Brien, Anna M. Basile, Leonardo Pantoni, Domenico Inzitari, Gunhild Waldemar on behalf of the LADIS study group

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520 |a Objective: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. Methods: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects. Results: 328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to nonconverters (p < 0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p < 0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p < 0.01). Conclusion: The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment. 
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700 1 |a Straaten, Elisabeth C. W. van  |e VerfasserIn  |4 aut 
700 1 |a Fazekas, Franz  |e VerfasserIn  |4 aut 
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700 1 |a Inzitari, Domenico  |e VerfasserIn  |4 aut 
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