Live-virus neutralization of the omicron variant in children and adults 14 months after SARS-CoV-2 wild-type infection
Data on cross-neutralization of the SARS-CoV-2 omicron variant more than 1 year after SARS-CoV-2 infection are urgently needed, especially in children, to predict the likelihood of reinfection and to guide vaccination strategies. In a prospective observational cohort study, we evaluated live-virus n...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
16 February 2023
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| In: |
Journal of medical virology
Year: 2023, Jahrgang: 95, Heft: 3, Pages: 1-11 |
| ISSN: | 1096-9071 |
| DOI: | 10.1002/jmv.28582 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/jmv.28582 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.28582 
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| Verfasserangaben: | Maximilian Stich, Louise Benning, Claudius Speer, Sven F. Garbade, Marie Bartenschlager, Heeyoung Kim, Kathrin Jeltsch, Julia Tabatabai, Moritz Niesert, Aleš Janda, Hanna Renk, Roland Elling, Georg Friedrich Hoffmann, Hans-Georg Kräusslich, Barbara Müller, Ralf Bartenschlager, Burkhard Tönshoff |
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| 245 | 1 | 0 | |a Live-virus neutralization of the omicron variant in children and adults 14 months after SARS-CoV-2 wild-type infection |c Maximilian Stich, Louise Benning, Claudius Speer, Sven F. Garbade, Marie Bartenschlager, Heeyoung Kim, Kathrin Jeltsch, Julia Tabatabai, Moritz Niesert, Aleš Janda, Hanna Renk, Roland Elling, Georg Friedrich Hoffmann, Hans-Georg Kräusslich, Barbara Müller, Ralf Bartenschlager, Burkhard Tönshoff |
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| 520 | |a Data on cross-neutralization of the SARS-CoV-2 omicron variant more than 1 year after SARS-CoV-2 infection are urgently needed, especially in children, to predict the likelihood of reinfection and to guide vaccination strategies. In a prospective observational cohort study, we evaluated live-virus neutralization of the SARS-CoV-2 omicron (BA.1) variant in children compared with adults 14 months after mild or asymptomatic wild-type SARS-CoV-2 infection. We also evaluated immunity to reinfection conferred by previous infection plus COVID-19 mRNA vaccination. We studied 36 adults and 34 children 14 months after acute SARS-CoV-2 infection. While 94% of unvaccinated adults (16/17) and children (32/34) neutralized the delta (B.1.617.2) variant, only 1/17 (5.9%) unvaccinated adults, 0/16 (0%) adolescents and 5/18 (27.8%) children <12 years of age had neutralizing activity against omicron (BA.1). In convalescent adults, one or two doses of mRNA vaccine increased delta and omicron neutralization 32-fold, similar to a third mRNA vaccination in uninfected adults. Neutralization of omicron was 8-fold lower than that of delta in both groups. In conclusion, our data indicate that humoral immunity induced by previous SARS-CoV-2 wild-type infection more than 1 year ago is insufficient to neutralize the current immune escape omicron variant. | ||
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