Comparing gene expression in deep infiltrating endometriosis with adenomyosis uteri: evidence for dysregulation of oncogene pathways
The pathogenesis of deep infiltrating endometriosis (DIE) is poorly understood. It is considered a benign disease but has histologic features of malignancy, such as local invasion or gene mutations. Moreover, it is not clear whether its invasive potential is comparable to that of adenomyosis uteri (...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 April 2023
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| In: |
Reproductive biology and endocrinology
Year: 2023, Volume: 21, Pages: 1-11 |
| ISSN: | 1477-7827 |
| DOI: | 10.1186/s12958-023-01083-9 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12958-023-01083-9
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| Author Notes: | A. Marshall, K.F. Kommoss, H. Ortmann, M. Kirchner, J. Jauckus, P. Sinn, T. Strowitzki and A. Germeyer |
| Summary: | The pathogenesis of deep infiltrating endometriosis (DIE) is poorly understood. It is considered a benign disease but has histologic features of malignancy, such as local invasion or gene mutations. Moreover, it is not clear whether its invasive potential is comparable to that of adenomyosis uteri (FA), or whether it has a different biological background. Therefore, the aim of this study was to molecularly characterize the gene expression signatures of both diseases in order to gain insight into the common or different underlying pathomechanisms and to provide clues to pathomechanisms of tumor development based on these diseases. |
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| Item Description: | Gesehen am 24.05.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1477-7827 |
| DOI: | 10.1186/s12958-023-01083-9 |