Control of sympathetic activity - new insights; new therapeutic targets?
Recently, a large international group of 25 investigators identified a candidate gene for hypertension which codes for phosducin (Pdc) as a novel player in the sympathetic nervous system [1]. In their study, a wide spectrum of findings documented its so-far unrecognized and apparently important role...
Gespeichert in:
| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
22 February 2010
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| In: |
Nephrology, dialysis, transplantation
Year: 2010, Jahrgang: 25, Heft: 4, Pages: 1048-1050 |
| ISSN: | 1460-2385 |
| DOI: | 10.1093/ndt/gfq079 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/ndt/gfq079
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| Verfasserangaben: | Eberhard Ritz and Lars Christian Rump |
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| 520 | |a Recently, a large international group of 25 investigators identified a candidate gene for hypertension which codes for phosducin (Pdc) as a novel player in the sympathetic nervous system [1]. In their study, a wide spectrum of findings documented its so-far unrecognized and apparently important role in experimental and human stress-induced hypertension. This conclusion is based on data ranging from detailed analyses of the sympathetic system in genetically manipulated Pdc −/− (knock-out) mice to the demonstration of its relevance in humans: in two separate cohorts, French Canadian and Afro-American individuals, respectively, a correlation was documented between single-nucleotide polymorphisms (SNPs) in the Pdc gene and stress-dependent blood pressure reactions. | ||
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