Stress triggers anhedonia in rats bred for learned helplessness
Congenitally helpless (cLH) rats, a well-accepted model for depression, show reduced consumption of sweet solutions only under single-housing conditions, indicating anhedonia under stress. We investigated if anhedonic-like behaviour, measured by a reduction of sweetened-condensed milk (SCM) intake a...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1 February 2010
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| In: |
Behavioural brain research
Year: 2010, Volume: 209, Issue: 1, Pages: 183-186 |
| ISSN: | 1872-7549 |
| DOI: | 10.1016/j.bbr.2010.01.042 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.bbr.2010.01.042 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0166432810000756 
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| Author Notes: | Thomas Enkel, Rainer Spanagel, Barbara Vollmayr, Miriam Schneider |
| Summary: | Congenitally helpless (cLH) rats, a well-accepted model for depression, show reduced consumption of sweet solutions only under single-housing conditions, indicating anhedonia under stress. We investigated if anhedonic-like behaviour, measured by a reduction of sweetened-condensed milk (SCM) intake and the pleasure-attenuated startle response (PAS), could be induced by an electric foot-shock stress challenge in group-housed rats. After foot-shock stress, reduced SCM intake was observed in cLH rats compared to non-helpless (cNLH) rats. Furthermore, cLH rats also showed a decreased PAS, indicating deficient reward perception. In summary, we demonstrate that a predisposition for learned helplessness interacts with stress to trigger anhedonic-like behaviour in cLH rats. These findings further add to the validity of congenitally learned helplessness as an animal model of depression, since gene-environment interactions are considered to play a role in the etiology of this disorder. |
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| Item Description: | Gesehen am 25.05.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1872-7549 |
| DOI: | 10.1016/j.bbr.2010.01.042 |