The roles of secreted wnt ligands in cancer
Wnt ligands are secreted signaling proteins that display a wide range of biological effects. They play key roles in stimulating Wnt signaling pathways to facilitate processes such as tissue homeostasis and regeneration. Dysregulation of Wnt signaling is a hallmark of many cancers and genetic alterat...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
30 January 2023
|
| In: |
International journal of molecular sciences
Year: 2023, Jahrgang: 24, Heft: 6, Pages: 1-27 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms24065349 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms24065349 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/24/6/5349 
|
| Verfasserangaben: | Johannes Werner, Kim E. Boonekamp, Tianzuo Zhan and Michael Boutros |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 184622814X | ||
| 003 | DE-627 | ||
| 005 | 20230720123006.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230525s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/ijms24065349 |2 doi | |
| 035 | |a (DE-627)184622814X | ||
| 035 | |a (DE-599)KXP184622814X | ||
| 035 | |a (OCoLC)1389529797 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Werner, Johannes |d 1998- |e VerfasserIn |0 (DE-588)1296735974 |0 (DE-627)1853186767 |4 aut | |
| 245 | 1 | 4 | |a The roles of secreted wnt ligands in cancer |c Johannes Werner, Kim E. Boonekamp, Tianzuo Zhan and Michael Boutros |
| 264 | 1 | |c 30 January 2023 | |
| 300 | |a 27 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.05.2025 | ||
| 520 | |a Wnt ligands are secreted signaling proteins that display a wide range of biological effects. They play key roles in stimulating Wnt signaling pathways to facilitate processes such as tissue homeostasis and regeneration. Dysregulation of Wnt signaling is a hallmark of many cancers and genetic alterations in various Wnt signaling components, which result in ligand-independent or ligand-dependent hyperactivation of the pathway that have been identified. Recently, research is focusing on the impact of Wnt signaling on the interaction between tumor cells and their micro-environment. This Wnt-mediated crosstalk can act either in a tumor promoting or suppressing fashion. In this review, we comprehensively outline the function of Wnt ligands in different tumor entities and their impact on key phenotypes, including cancer stemness, drug resistance, metastasis, and immune evasion. Lastly, we elaborate approaches to target Wnt ligands in cancer therapy. | ||
| 650 | 4 | |a cancer | |
| 650 | 4 | |a immunotherapy | |
| 650 | 4 | |a metastasis | |
| 650 | 4 | |a non-canonical Wnt signaling | |
| 650 | 4 | |a targeted therapy | |
| 650 | 4 | |a tumor microenvironment | |
| 650 | 4 | |a Wnt ligands | |
| 650 | 4 | |a Wnt signaling | |
| 700 | 1 | |a Boonekamp, Kim E. |e VerfasserIn |0 (DE-588)1296739244 |0 (DE-627)185319137X |4 aut | |
| 700 | 1 | |a Zhan, Tianzuo |d 1985- |e VerfasserIn |0 (DE-588)1019998911 |0 (DE-627)691070105 |0 (DE-576)359019544 |4 aut | |
| 700 | 1 | |a Boutros, Michael |e VerfasserIn |0 (DE-588)1023031132 |0 (DE-627)717350045 |0 (DE-576)366291831 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of molecular sciences |d Basel : Molecular Diversity Preservation International, 2000 |g 24(2023), 6, Artikel-ID 5349, Seite 1-27 |h Online-Ressource |w (DE-627)316340715 |w (DE-600)2019364-6 |w (DE-576)281194653 |x 1422-0067 |7 nnas |a The roles of secreted wnt ligands in cancer |
| 773 | 1 | 8 | |g volume:24 |g year:2023 |g number:6 |g elocationid:5349 |g pages:1-27 |g extent:27 |a The roles of secreted wnt ligands in cancer |
| 856 | 4 | 0 | |u https://doi.org/10.3390/ijms24065349 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/1422-0067/24/6/5349 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230526 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1023031132 |a Boutros, Michael |m 1023031132:Boutros, Michael |d 60000 |e 60000PB1023031132 |k 0/60000/ |p 4 |y j | ||
| 998 | |g 1019998911 |a Zhan, Tianzuo |m 1019998911:Zhan, Tianzuo |d 60000 |d 61100 |e 60000PZ1019998911 |e 61100PZ1019998911 |k 0/60000/ |k 1/60000/61100/ |p 3 | ||
| 998 | |g 1296739244 |a Boonekamp, Kim E. |m 1296739244:Boonekamp, Kim E. |d 140000 |e 140000PB1296739244 |k 0/140000/ |p 2 | ||
| 998 | |g 1296735974 |a Werner, Johannes |m 1296735974:Werner, Johannes |d 50000 |e 50000PW1296735974 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN184622814X |e 4325429476 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"184622814X","name":{"displayForm":["Johannes Werner, Kim E. Boonekamp, Tianzuo Zhan and Michael Boutros"]},"physDesc":[{"extent":"27 S."}],"relHost":[{"id":{"issn":["1422-0067","1661-6596"],"eki":["316340715"],"zdb":["2019364-6"]},"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["1.2000 -"],"recId":"316340715","origin":[{"dateIssuedDisp":"2000-","publisherPlace":"Basel","publisher":"Molecular Diversity Preservation International","dateIssuedKey":"2000"}],"note":["Gesehen am 17.09.20"],"type":{"media":"Online-Ressource","bibl":"periodical"},"titleAlt":[{"title":"IJMS"}],"title":[{"title":"International journal of molecular sciences","title_sort":"International journal of molecular sciences"}],"part":{"volume":"24","extent":"27","text":"24(2023), 6, Artikel-ID 5349, Seite 1-27","pages":"1-27","year":"2023","issue":"6"},"language":["eng"],"disp":"The roles of secreted wnt ligands in cancerInternational journal of molecular sciences"}],"id":{"doi":["10.3390/ijms24065349"],"eki":["184622814X"]},"person":[{"display":"Werner, Johannes","family":"Werner","given":"Johannes","role":"aut"},{"role":"aut","given":"Kim E.","family":"Boonekamp","display":"Boonekamp, Kim E."},{"display":"Zhan, Tianzuo","family":"Zhan","role":"aut","given":"Tianzuo"},{"given":"Michael","role":"aut","display":"Boutros, Michael","family":"Boutros"}],"language":["eng"],"note":["Gesehen am 25.05.2025"],"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"30 January 2023"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title":"The roles of secreted wnt ligands in cancer","title_sort":"roles of secreted wnt ligands in cancer"}]} | ||
| SRT | |a WERNERJOHAROLESOFSEC3020 | ||